778 Risk of 27 cancer types in relation to tobacco smoking: cohort study involving 229,028 Australians

Marianne Weber, Peter Sarich, P Vaneckova, Stephen Wade, Emily Banks, Sam Egger, Preston Ngo, Grace Joshy, David Goldsbury , S Yap, Amy Vassallo, Eleonora Feletto

    Research output: Contribution to journalMeeting Abstractpeer-review

    Abstract

    Background Tobacco smoke is a known carcinogen and the magnitude of smoking-related cancer risk varies according to time and population. Local, contemporary evidence can drive appropriate tobacco control. We provide comprehensive cancer risk estimates related to smoking in the population-based, New South Wales (NSW) 45 and Up Study. Methods We estimated smoking-related hazard ratios (HR) for cancer using Cox proportional hazards regression using linked questionnaire (2006-2009) and incident cancer data (n≥50 cases per cancer type), from the NSW Cancer Registry (to December 2013) (via CHeReL). Results Of 18,475 cancers among 229,028 participants aged ≥45 years, current smokers had significantly increased risks of cancers of the lung, larynx, head and neck, oesophagus, liver, bladder, pancreas, stomach, colorectum, and cancers with unknown primary site, compared to never-smokers; lung cancer risk was markedly elevated, including for current-smokers of 1-5 cigarettes/day (HR=9.25, 95%CI=5.2-16.6), increasing to 38.39 (26.2-56.2) for current-smokers of>30 cigarettes/day. Quitting substantively decreased cancer risk compared to continued smoking, with lung cancer risk decreasing with decreasing age at quitting (p(trend)<0.05), however risks remained elevated for those quitting aged >25 compared to never-smokers (1.73, 1.1-2.6 for age 26-30 years). An estimated 20% of current-smokers in Australia will get lung cancer during their lifetime versus 1.6% of never-smokers. Conclusions Smoking-attributable cancer risks in Australia are significant, comparable to contemporary risks from other developed nations.
    Original languageEnglish
    JournalInternational Journal of Epidemiology Volume 50, Issue Supplement_1 September 2021
    Volume50
    Issue number1
    DOIs
    Publication statusPublished - 2021
    EventIAE World Congress Of Epidemiology 2021 - Level 11, 87 Wickham Terrace Spring Hill QLD 4000
    Duration: 1 Jan 2021 → …
    https://academic.oup.com/ije/issue/50/Supplement_1

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