A benchmarking study of Geant4 for Auger electrons emitted by medical radioisotopes

Samer Bakr; Tibor Kibédi; Bryan Tee; David Bolst; Maarten Vos; Mohammed Alotiby; Laurent Desorgher; Dennis Herbert Wright; Alfonso Mantero; Anatoly Rosenfeld; Vladimir Ivanchenko; Sebastien Incerti; Susanna Guatelli

doi:10.1016/j.apradiso.2021.109777

A benchmarking study of Geant4 for Auger electrons emitted by medical radioisotopes

Samer Bakr^*, Tibor Kibédi, Bryan Tee, David Bolst, Maarten Vos, Mohammed Alotiby, Laurent Desorgher, Dennis Herbert Wright, Alfonso Mantero, Anatoly Rosenfeld, Vladimir Ivanchenko, Sebastien Incerti, Susanna Guatelli

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Auger emitting radioisotopes are of great interest in targeted radiotherapy because, once internalised in the tumour cells, they can deliver dose locally to the radiation sensitive targets, while not affecting surrounding cells. Geant4 is a Monte Carlo code widely used to characterise the physics mechanism at the basis of targeted radiotherapy. In this work, we benchmarked the modelling of the emission of Auger electrons in Geant4 deriving from the decay of ¹²³I, ¹²⁴I, ¹²⁵I radionuclides against existing theoretical approaches. We also compared Geant4 against reference data in the case of ¹³¹Cs, which is of interest for brachytherapy. In the case of ¹²⁵I and ¹³¹Cs, the simulation results are compared to experimental measurements as well. Good agreement was found between Geant4 and the reference data. As far as we know, this is the first study aimed to benchmark against experimental measurements the emission of Auger electrons in Geant4 for radiotherapy applications.

Original language	English
Article number	109777
Journal	Applied Radiation and Isotopes
Volume	174
DOIs	https://doi.org/10.1016/j.apradiso.2021.109777
Publication status	Published - Aug 2021

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title = "A benchmarking study of Geant4 for Auger electrons emitted by medical radioisotopes",

abstract = "Auger emitting radioisotopes are of great interest in targeted radiotherapy because, once internalised in the tumour cells, they can deliver dose locally to the radiation sensitive targets, while not affecting surrounding cells. Geant4 is a Monte Carlo code widely used to characterise the physics mechanism at the basis of targeted radiotherapy. In this work, we benchmarked the modelling of the emission of Auger electrons in Geant4 deriving from the decay of 123I, 124I, 125I radionuclides against existing theoretical approaches. We also compared Geant4 against reference data in the case of 131Cs, which is of interest for brachytherapy. In the case of 125I and 131Cs, the simulation results are compared to experimental measurements as well. Good agreement was found between Geant4 and the reference data. As far as we know, this is the first study aimed to benchmark against experimental measurements the emission of Auger electrons in Geant4 for radiotherapy applications.",

keywords = "Auger electron, Geant4, Monte Carlo, Radioactive decay",

author = "Samer Bakr and Tibor Kib{\'e}di and Bryan Tee and David Bolst and Maarten Vos and Mohammed Alotiby and Laurent Desorgher and Wright, {Dennis Herbert} and Alfonso Mantero and Anatoly Rosenfeld and Vladimir Ivanchenko and Sebastien Incerti and Susanna Guatelli",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = aug,

doi = "10.1016/j.apradiso.2021.109777",

language = "English",

volume = "174",

journal = "Applied Radiation and Isotopes",

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TY - JOUR

T1 - A benchmarking study of Geant4 for Auger electrons emitted by medical radioisotopes

AU - Bakr, Samer

AU - Kibédi, Tibor

AU - Tee, Bryan

AU - Bolst, David

AU - Vos, Maarten

AU - Alotiby, Mohammed

AU - Desorgher, Laurent

AU - Wright, Dennis Herbert

AU - Mantero, Alfonso

AU - Rosenfeld, Anatoly

AU - Ivanchenko, Vladimir

AU - Incerti, Sebastien

AU - Guatelli, Susanna

PY - 2021/8

Y1 - 2021/8

N2 - Auger emitting radioisotopes are of great interest in targeted radiotherapy because, once internalised in the tumour cells, they can deliver dose locally to the radiation sensitive targets, while not affecting surrounding cells. Geant4 is a Monte Carlo code widely used to characterise the physics mechanism at the basis of targeted radiotherapy. In this work, we benchmarked the modelling of the emission of Auger electrons in Geant4 deriving from the decay of 123I, 124I, 125I radionuclides against existing theoretical approaches. We also compared Geant4 against reference data in the case of 131Cs, which is of interest for brachytherapy. In the case of 125I and 131Cs, the simulation results are compared to experimental measurements as well. Good agreement was found between Geant4 and the reference data. As far as we know, this is the first study aimed to benchmark against experimental measurements the emission of Auger electrons in Geant4 for radiotherapy applications.

AB - Auger emitting radioisotopes are of great interest in targeted radiotherapy because, once internalised in the tumour cells, they can deliver dose locally to the radiation sensitive targets, while not affecting surrounding cells. Geant4 is a Monte Carlo code widely used to characterise the physics mechanism at the basis of targeted radiotherapy. In this work, we benchmarked the modelling of the emission of Auger electrons in Geant4 deriving from the decay of 123I, 124I, 125I radionuclides against existing theoretical approaches. We also compared Geant4 against reference data in the case of 131Cs, which is of interest for brachytherapy. In the case of 125I and 131Cs, the simulation results are compared to experimental measurements as well. Good agreement was found between Geant4 and the reference data. As far as we know, this is the first study aimed to benchmark against experimental measurements the emission of Auger electrons in Geant4 for radiotherapy applications.

KW - Auger electron

KW - Geant4

KW - Monte Carlo

KW - Radioactive decay

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U2 - 10.1016/j.apradiso.2021.109777

DO - 10.1016/j.apradiso.2021.109777

M3 - Article

SN - 0969-8043

VL - 174

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 109777

ER -

A benchmarking study of Geant4 for Auger electrons emitted by medical radioisotopes

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