A chemoenzymatic and enantioselective total synthesis of the resorcylic acid lactone L-783,290, the trans-isomer of L-783,277

Andrew Lin; Anthony C. Willis; Martin G. Banwell

doi:10.1016/j.tetlet.2009.12.067

A chemoenzymatic and enantioselective total synthesis of the resorcylic acid lactone L-783,290, the trans-isomer of L-783,277

Andrew Lin, Anthony C. Willis, Martin G. Banwell^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The structure, 5, assigned to the resorcylic acid lactone L-783,290 has been prepared for the first time and in a modular fashion using a Heck reaction to link the readily available fragments 8 and 14. Chemoenzymatic methods were used to prepare the latter fragment, in enantiopure form, from chlorobenzene.

Original language	English
Pages (from-to)	1044-1047
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	7
DOIs	https://doi.org/10.1016/j.tetlet.2009.12.067
Publication status	Published - 17 Feb 2010

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10.1016/j.tetlet.2009.12.067

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abstract = "The structure, 5, assigned to the resorcylic acid lactone L-783,290 has been prepared for the first time and in a modular fashion using a Heck reaction to link the readily available fragments 8 and 14. Chemoenzymatic methods were used to prepare the latter fragment, in enantiopure form, from chlorobenzene.",

keywords = "Chemoenzymatic, Heck reaction, Resorcylic acid lactones, Ring-closing metathesis, Synthesis",

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AU - Lin, Andrew

AU - Willis, Anthony C.

AU - Banwell, Martin G.

PY - 2010/2/17

Y1 - 2010/2/17

N2 - The structure, 5, assigned to the resorcylic acid lactone L-783,290 has been prepared for the first time and in a modular fashion using a Heck reaction to link the readily available fragments 8 and 14. Chemoenzymatic methods were used to prepare the latter fragment, in enantiopure form, from chlorobenzene.

AB - The structure, 5, assigned to the resorcylic acid lactone L-783,290 has been prepared for the first time and in a modular fashion using a Heck reaction to link the readily available fragments 8 and 14. Chemoenzymatic methods were used to prepare the latter fragment, in enantiopure form, from chlorobenzene.

KW - Chemoenzymatic

KW - Heck reaction

KW - Resorcylic acid lactones

KW - Ring-closing metathesis

KW - Synthesis

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DO - 10.1016/j.tetlet.2009.12.067

M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 7

ER -

A chemoenzymatic and enantioselective total synthesis of the resorcylic acid lactone L-783,290, the trans-isomer of L-783,277

Abstract

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