TY - JOUR
T1 - A composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium
AU - Hall, Damien
N1 - Publisher Copyright:
© 2017
PY - 2017/9
Y1 - 2017/9
N2 - A different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial.
AB - A different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial.
UR - http://www.scopus.com/inward/record.url?scp=85020776498&partnerID=8YFLogxK
U2 - 10.1016/j.bpc.2017.06.002
DO - 10.1016/j.bpc.2017.06.002
M3 - Letter
SN - 0301-4622
VL - 228
SP - 10
EP - 16
JO - Biophysical Chemistry
JF - Biophysical Chemistry
ER -