A composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium

Damien Hall

doi:10.1016/j.bpc.2017.06.002

A composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium

Damien Hall

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

A different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial.

Original language	English
Pages (from-to)	10-16
Number of pages	7
Journal	Biophysical Chemistry
Volume	228
DOIs	https://doi.org/10.1016/j.bpc.2017.06.002
Publication status	Published - Sept 2017
Externally published	Yes

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10.1016/j.bpc.2017.06.002

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title = "A composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium",

abstract = "A different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial.",

author = "Damien Hall",

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doi = "10.1016/j.bpc.2017.06.002",

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AU - Hall, Damien

PY - 2017/9

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N2 - A different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial.

AB - A different approach is described for analyzing sedimentation equilibrium experiments of indefinitely self-associating systems. The procedure involves application of conservation of mass criteria, along with local evaluation of the weight average molar mass, to generate a polynomial based on a composite pseudo-independent variable. The outlined method does not depend upon non-linear regression to generate a solution, but instead requires evaluation of the roots of a high-order polynomial.

UR - https://www.scopus.com/pages/publications/85020776498

U2 - 10.1016/j.bpc.2017.06.002

DO - 10.1016/j.bpc.2017.06.002

M3 - Letter

SN - 0301-4622

VL - 228

SP - 10

EP - 16

JO - Biophysical Chemistry

JF - Biophysical Chemistry

ER -

A composite polynomial approach for analyzing the indefinite self-association of macromolecules studied by sedimentation equilibrium

Abstract

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