A convenient synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid

David Barker; Margaret A. Brimble; Malcolm D. McLeod

doi:10.1055/s-2003-38065

A convenient synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid

David Barker, Margaret A. Brimble^*, Malcolm D. McLeod

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A new procedure for the synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1yl)benzoic acid (3) is reported via hydrogenation of 2-(3-methyl-2,5-dihydropyrrol-1-yl)benzoic acid (9) that in turn is available from fusion of anthranilic acid with citraconic anhydride. This method provides cleaner material in higher overall yield than that obtained using previously reported methods.

Original language	English
Pages (from-to)	656-658
Number of pages	3
Journal	Synthesis
Issue number	5
DOIs	https://doi.org/10.1055/s-2003-38065
Publication status	Published - 2003
Externally published	Yes

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title = "A convenient synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid",

abstract = "A new procedure for the synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1yl)benzoic acid (3) is reported via hydrogenation of 2-(3-methyl-2,5-dihydropyrrol-1-yl)benzoic acid (9) that in turn is available from fusion of anthranilic acid with citraconic anhydride. This method provides cleaner material in higher overall yield than that obtained using previously reported methods.",

keywords = "Acids, Alkaloids, Amines, Anhydrides, Hydrogenation",

author = "David Barker and Brimble, {Margaret A.} and McLeod, {Malcolm D.}",

year = "2003",

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language = "English",

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journal = "Synthesis",

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T1 - A convenient synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid

AU - Barker, David

AU - Brimble, Margaret A.

AU - McLeod, Malcolm D.

PY - 2003

Y1 - 2003

N2 - A new procedure for the synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1yl)benzoic acid (3) is reported via hydrogenation of 2-(3-methyl-2,5-dihydropyrrol-1-yl)benzoic acid (9) that in turn is available from fusion of anthranilic acid with citraconic anhydride. This method provides cleaner material in higher overall yield than that obtained using previously reported methods.

AB - A new procedure for the synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1yl)benzoic acid (3) is reported via hydrogenation of 2-(3-methyl-2,5-dihydropyrrol-1-yl)benzoic acid (9) that in turn is available from fusion of anthranilic acid with citraconic anhydride. This method provides cleaner material in higher overall yield than that obtained using previously reported methods.

KW - Acids

KW - Alkaloids

KW - Amines

KW - Anhydrides

KW - Hydrogenation

UR - http://www.scopus.com/inward/record.url?scp=0037252397&partnerID=8YFLogxK

U2 - 10.1055/s-2003-38065

DO - 10.1055/s-2003-38065

M3 - Article

SN - 0039-7881

SP - 656

EP - 658

JO - Synthesis

JF - Synthesis

IS - 5

ER -

A convenient synthesis of 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)benzoic acid

Abstract

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