A deficit of detoxification enzymes: pesticide sensivitity and environmental response in the honeybee

Charles Claudianos; Hilary Ranson; R M Johnson; Sunita Biswas; M A Schuler; M R Berenbaum; R Feyereisen; John Graham Oakeshott

doi:10.1111/j.1365-2583.2006.00672.x

A deficit of detoxification enzymes: pesticide sensivitity and environmental response in the honeybee

Charles Claudianos, Hilary Ranson, R M Johnson, Sunita Biswas, M A Schuler, M R Berenbaum, R Feyereisen, John Graham Oakeshott

Research output: Contribution to journal › Article › peer-review

596 Citations (Scopus)

Abstract

The honeybee genome has substantially fewer protein coding genes (â‰ˆ 11 000 genes) than Drosophila melanogaster (â‰ˆ 13 500) and Anopheles gambiae (â‰ˆ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione-S-transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10-fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.

Original language	English
Pages (from-to)	615-636
Journal	Insect Molecular Biology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2583.2006.00672.x
Publication status	Published - 2006

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title = "A deficit of detoxification enzymes: pesticide sensivitity and environmental response in the honeybee",

abstract = "The honeybee genome has substantially fewer protein coding genes ({\^a}‰ˆ 11 000 genes) than Drosophila melanogaster ({\^a}‰ˆ 13 500) and Anopheles gambiae ({\^a}‰ˆ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione-S-transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10-fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.",

author = "Charles Claudianos and Hilary Ranson and Johnson, {R M} and Sunita Biswas and Schuler, {M A} and Berenbaum, {M R} and R Feyereisen and Oakeshott, {John Graham}",

year = "2006",

doi = "10.1111/j.1365-2583.2006.00672.x",

language = "English",

volume = "15",

pages = "615--636",

journal = "Insect Molecular Biology",

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T1 - A deficit of detoxification enzymes: pesticide sensivitity and environmental response in the honeybee

AU - Claudianos, Charles

AU - Ranson, Hilary

AU - Johnson, R M

AU - Biswas, Sunita

AU - Schuler, M A

AU - Berenbaum, M R

AU - Feyereisen, R

AU - Oakeshott, John Graham

PY - 2006

Y1 - 2006

N2 - The honeybee genome has substantially fewer protein coding genes (â‰ˆ 11 000 genes) than Drosophila melanogaster (â‰ˆ 13 500) and Anopheles gambiae (â‰ˆ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione-S-transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10-fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.

AB - The honeybee genome has substantially fewer protein coding genes (â‰ˆ 11 000 genes) than Drosophila melanogaster (â‰ˆ 13 500) and Anopheles gambiae (â‰ˆ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione-S-transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10-fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.

U2 - 10.1111/j.1365-2583.2006.00672.x

DO - 10.1111/j.1365-2583.2006.00672.x

M3 - Article

VL - 15

SP - 615

EP - 636

JO - Insect Molecular Biology

JF - Insect Molecular Biology

IS - 5

ER -

A deficit of detoxification enzymes: pesticide sensivitity and environmental response in the honeybee

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