A disanalogy with RCTs and its implications for second-generation causal knowledge

Kate E. Lynch; Rachael L. Brown; Jeremy Strasser; Shang Long Yeo

doi:10.1017/S0140525X22002242

A disanalogy with RCTs and its implications for second-generation causal knowledge

Kate E. Lynch, Rachael L. Brown, Jeremy Strasser, Shang Long Yeo

Research output: Contribution to journal › Review article › peer-review

Abstract

We are less optimistic than Madole & Harden that family-based genome-wide association studies (GWASs) will lead to significant second-generation causal knowledge. Despite bearing some similarities, family-based GWASs and randomised controlled trials (RCTs) are not identical. Most RCTs assess a relatively homogenous causal stimulus as a treatment, whereas GWASs assess highly heterogeneous causal stimuli. Thus, GWAS results will not translate so easily into second-generation causal knowledge.

Original language	English
Article number	e194
Journal	Behavioral and Brain Sciences
Volume	46
DOIs	https://doi.org/10.1017/S0140525X22002242
Publication status	Published - 11 Sept 2023

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abstract = "We are less optimistic than Madole & Harden that family-based genome-wide association studies (GWASs) will lead to significant second-generation causal knowledge. Despite bearing some similarities, family-based GWASs and randomised controlled trials (RCTs) are not identical. Most RCTs assess a relatively homogenous causal stimulus as a treatment, whereas GWASs assess highly heterogeneous causal stimuli. Thus, GWAS results will not translate so easily into second-generation causal knowledge.",

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AU - Strasser, Jeremy

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N2 - We are less optimistic than Madole & Harden that family-based genome-wide association studies (GWASs) will lead to significant second-generation causal knowledge. Despite bearing some similarities, family-based GWASs and randomised controlled trials (RCTs) are not identical. Most RCTs assess a relatively homogenous causal stimulus as a treatment, whereas GWASs assess highly heterogeneous causal stimuli. Thus, GWAS results will not translate so easily into second-generation causal knowledge.

AB - We are less optimistic than Madole & Harden that family-based genome-wide association studies (GWASs) will lead to significant second-generation causal knowledge. Despite bearing some similarities, family-based GWASs and randomised controlled trials (RCTs) are not identical. Most RCTs assess a relatively homogenous causal stimulus as a treatment, whereas GWASs assess highly heterogeneous causal stimuli. Thus, GWAS results will not translate so easily into second-generation causal knowledge.

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DO - 10.1017/S0140525X22002242

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JO - Behavioral and Brain Sciences

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A disanalogy with RCTs and its implications for second-generation causal knowledge

Abstract

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