A first generation chemoenzymatic synthesis of (+)-galanthamine

Martin G. Banwell, Xinghua Ma, Ochitha P. Karunaratne, Anthony C. Willis

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    30 Citations (Scopus)


    A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the EschenmoserClaisen rearrangement reaction.

    Original languageEnglish
    Pages (from-to)1437-1447
    Number of pages11
    JournalAustralian Journal of Chemistry
    Issue number10
    Publication statusPublished - 2010


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