A first generation chemoenzymatic synthesis of (+)-galanthamine

Martin G. Banwell; Xinghua Ma; Ochitha P. Karunaratne; Anthony C. Willis

doi:10.1071/CH10201

A first generation chemoenzymatic synthesis of (+)-galanthamine

Martin G. Banwell, Xinghua Ma, Ochitha P. Karunaratne, Anthony C. Willis

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35 Citations (Scopus)

Abstract

A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the EschenmoserClaisen rearrangement reaction.

Original language	English
Pages (from-to)	1437-1447
Number of pages	11
Journal	Australian Journal of Chemistry
Volume	63
Issue number	10
DOIs	https://doi.org/10.1071/CH10201
Publication status	Published - 2010

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title = "A first generation chemoenzymatic synthesis of (+)-galanthamine",

abstract = "A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the EschenmoserClaisen rearrangement reaction.",

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AU - Willis, Anthony C.

PY - 2010

Y1 - 2010

N2 - A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the EschenmoserClaisen rearrangement reaction.

AB - A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the EschenmoserClaisen rearrangement reaction.

UR - https://www.scopus.com/pages/publications/77957701536

U2 - 10.1071/CH10201

DO - 10.1071/CH10201

M3 - Article

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VL - 63

SP - 1437

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JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

IS - 10

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A first generation chemoenzymatic synthesis of (+)-galanthamine

Abstract

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