A hyperactive mutant of interferon-regulatory factor 4

Chol Ho Kang; Enno Hartmann; Lisa Menke; Daniel Staudenraus; El Fadil Abass; Hartmann Raifer; Alekya Porapu; Bärbel Camara; Anne Brüstle; Olaf Pinkenburg; Maria Bieringer; Michael Lohoff

doi:10.1002/eji.201847530

A hyperactive mutant of interferon-regulatory factor 4

Chol Ho Kang
, Enno Hartmann
, Lisa Menke
, Daniel Staudenraus
, El Fadil Abass
, Hartmann Raifer
, Alekya Porapu
, Bärbel Camara
, Anne Brüstle
, Olaf Pinkenburg
, Maria Bieringer
, Michael Lohoff^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferonregulatory factor) Cterminus creates hyperactive IRF4. When introduced into IRF4deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2linked IL13 production were much less altered.

Original language	English
Pages (from-to)	812-815
Number of pages	4
Journal	European Journal of Immunology
Volume	49
Issue number	5
DOIs	https://doi.org/10.1002/eji.201847530
Publication status	Published - May 2019

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@article{10002a7818c94923a67ee1463ac3cc4a,

title = "A hyperactive mutant of interferon-regulatory factor 4",

abstract = "We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferonregulatory factor) Cterminus creates hyperactive IRF4. When introduced into IRF4deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2linked IL13 production were much less altered.",

keywords = "IRF4, Mutation, T cell differentiation, Th17, Transcriptional activity",

author = "Kang, \{Chol Ho\} and Enno Hartmann and Lisa Menke and Daniel Staudenraus and Abass, \{El Fadil\} and Hartmann Raifer and Alekya Porapu and B{\"a}rbel Camara and Anne Br{\"u}stle and Olaf Pinkenburg and Maria Bieringer and Michael Lohoff",

year = "2019",

month = may,

doi = "10.1002/eji.201847530",

language = "English",

volume = "49",

pages = "812--815",

journal = "European Journal of Immunology",

issn = "0014-2980",

publisher = "Wiley-VCH Verlag GmbH",

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}

TY - JOUR

T1 - A hyperactive mutant of interferon-regulatory factor 4

AU - Kang, Chol Ho

AU - Hartmann, Enno

AU - Menke, Lisa

AU - Staudenraus, Daniel

AU - Abass, El Fadil

AU - Raifer, Hartmann

AU - Porapu, Alekya

AU - Camara, Bärbel

AU - Brüstle, Anne

AU - Pinkenburg, Olaf

AU - Bieringer, Maria

AU - Lohoff, Michael

PY - 2019/5

Y1 - 2019/5

N2 - We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferonregulatory factor) Cterminus creates hyperactive IRF4. When introduced into IRF4deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2linked IL13 production were much less altered.

AB - We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferonregulatory factor) Cterminus creates hyperactive IRF4. When introduced into IRF4deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2linked IL13 production were much less altered.

KW - IRF4

KW - Mutation

KW - T cell differentiation

KW - Th17

KW - Transcriptional activity

UR - https://www.scopus.com/pages/publications/85054190069

U2 - 10.1002/eji.201847530

DO - 10.1002/eji.201847530

M3 - Letter

SN - 0014-2980

VL - 49

SP - 812

EP - 815

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 5

ER -

A hyperactive mutant of interferon-regulatory factor 4

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