A hypothetical mechanism of bone remodeling and modeling under electromagnetic loads

Chuanyong Qu; Qing Hua Qin; Yilan Kang

doi:10.1016/j.biomaterials.2006.03.015

A hypothetical mechanism of bone remodeling and modeling under electromagnetic loads

Chuanyong Qu, Qing Hua Qin^*, Yilan Kang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

A hypothetical regulation mechanism for bone modeling and remodeling under electromagnetic field is proposed. In this hypothesis, the bone modeling and remodeling mechanism is described as follows: the circular loads that we bear during ordinary daily activities generate micro-damage in cortical bone and these micro-cracks are removed by osteoclasts. Then growth factors, which are in latent forms in osteocytes, are activated by osteoclasts and released into bone fluid. These growth factors stimulate osteoblasts to refill the cavities. An electromagnetic field can stimulate the multiplication of growth factors and accelerate the bone remodeling process indirectly. It can be seen that many features reported in adaptive bone modeling and remodeling are explained by the proposed hypothesis. Further, a computational model is established based on the hypothesis, which can simulate the bone modeling and remodeling process under multi-field loads.

Original language	English
Pages (from-to)	4050-4057
Number of pages	8
Journal	Biomaterials
Volume	27
Issue number	21
DOIs	https://doi.org/10.1016/j.biomaterials.2006.03.015
Publication status	Published - Jul 2006

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10.1016/j.biomaterials.2006.03.015

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title = "A hypothetical mechanism of bone remodeling and modeling under electromagnetic loads",

abstract = "A hypothetical regulation mechanism for bone modeling and remodeling under electromagnetic field is proposed. In this hypothesis, the bone modeling and remodeling mechanism is described as follows: the circular loads that we bear during ordinary daily activities generate micro-damage in cortical bone and these micro-cracks are removed by osteoclasts. Then growth factors, which are in latent forms in osteocytes, are activated by osteoclasts and released into bone fluid. These growth factors stimulate osteoblasts to refill the cavities. An electromagnetic field can stimulate the multiplication of growth factors and accelerate the bone remodeling process indirectly. It can be seen that many features reported in adaptive bone modeling and remodeling are explained by the proposed hypothesis. Further, a computational model is established based on the hypothesis, which can simulate the bone modeling and remodeling process under multi-field loads.",

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AU - Qin, Qing Hua

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AB - A hypothetical regulation mechanism for bone modeling and remodeling under electromagnetic field is proposed. In this hypothesis, the bone modeling and remodeling mechanism is described as follows: the circular loads that we bear during ordinary daily activities generate micro-damage in cortical bone and these micro-cracks are removed by osteoclasts. Then growth factors, which are in latent forms in osteocytes, are activated by osteoclasts and released into bone fluid. These growth factors stimulate osteoblasts to refill the cavities. An electromagnetic field can stimulate the multiplication of growth factors and accelerate the bone remodeling process indirectly. It can be seen that many features reported in adaptive bone modeling and remodeling are explained by the proposed hypothesis. Further, a computational model is established based on the hypothesis, which can simulate the bone modeling and remodeling process under multi-field loads.

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JO - Biomaterials

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A hypothetical mechanism of bone remodeling and modeling under electromagnetic loads

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