A minimum reporting standard for multiple sequence alignments

Thomas K.F. Wong; Subha Kalyaanamoorthy; Karen Meusemann; David K. Yeates; Bernhard Misof; Lars S. Jermiin

doi:10.1093/nargab/lqaa024

A minimum reporting standard for multiple sequence alignments

Thomas K.F. Wong, Subha Kalyaanamoorthy, Karen Meusemann, David K. Yeates, Bernhard Misof, Lars S. Jermiin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Multiple sequence alignments (MSAs) play a pivotal role in studies of molecular sequence data, but nobody has developed a minimum reporting standard (MRS) to quantify the completeness of MSAs in terms of completely specified nucleotides or amino acids. We present an MRS that relies on four simple completeness metrics. The metrics are implemented in AliStat, a program developed to support the MRS. A survey of published MSAs illustrates the benefits and unprecedented transparency offered by the MRS.

Original language	English
Article number	lqaa024
Journal	NAR Genomics and Bioinformatics
Volume	2
Issue number	2
DOIs	https://doi.org/10.1093/nargab/lqaa024
Publication status	Published - 1 Jun 2020

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AU - Misof, Bernhard

AU - Jermiin, Lars S.

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A minimum reporting standard for multiple sequence alignments

Abstract

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