A model of calcium channels

Ben Corry, Toby W. Allen, Serdar Kuyucak, Shin Ho Chung*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)


    We propose a model of calcium channels that can explain most of their observed properties, including the anomalous mole fraction effect and mutation of the glutamate residues. The structure grossly resembles that of the KcsA potassium channel except for the presence of an extracellular vestibule and a shorter selectivity filter containing four glutamate residues. Using this model in electrostatic calculations and Brownian dynamics simulations, we study mechanisms of ion permeation and selectivity in the channel. Potential energy profiles calculated for multiple ions in the channel provide explanations of ion permeation, the block of Na+ currents by Ca2+ ions, and many other observed properties. Brownian dynamics simulations provide quantitative predictions for the channel currents which reproduce available experimental data. (C) 2000 Elsevier Science B.V.

    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalBiochimica et Biophysica Acta - Biomembranes
    Issue number1-2
    Publication statusPublished - 20 Dec 2000


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