A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial

Darren J. Gray; Yue Sheng Li; Gail M. Williams; Zheng Yuan Zhao; Donald A. Harn; Sheng Ming Li; Mao Yuan Ren; Zeng Feng; Feng Ying Guo; Jia Gang Guo; Jie Zhou; Yu Lan Dong; Yuan Li; Allen G. Ross; Donald P. McManus

doi:10.1016/j.ijpara.2014.05.005

A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial

Darren J. Gray, Yue Sheng Li, Gail M. Williams, Zheng Yuan Zhao, Donald A. Harn, Sheng Ming Li, Mao Yuan Ren, Zeng Feng, Feng Ying Guo, Jia Gang Guo, Jie Zhou, Yu Lan Dong, Yuan Li, Allen G. Ross, Donald P. McManus^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Despite major successes in its control over the past 50. years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result in new habitats for the oncomelanid intermediate snail host of Schistosoma japonicum (Sj), thereby increasing the risk of transmission. The current national control program for P.R. China involves a multi-component integrated strategy but, despite targeting multiple transmission pathways, certain challenges remain. As the Chinese government pushes towards elimination, there is a requirement for additional tools, such as vaccination, for long-term prevention. Whereas the zoonotic nature of schistosomiasis japonica adds to the complexity of control, it provides a unique opportunity to develop a transmission blocking vaccine targeting bovines to assist in the prevention of human infection and disease. Mathematical modelling has shown that control options targeting the various transmission pathways of schistosomiasis japonica and incorporating bovine vaccination, mass human chemotherapy and mollusciciding could lead to its elimination from P.R. China. Here we present the study design and baseline results of a four-year cluster randomised intervention trial we are undertaking around the schistosomiasis-endemic Dongting Lake in Hunan Province aimed at determining the impact on schistosome transmission of the multi-component integrated control strategy, including bovine vaccination using a heterologous "prime-boost" delivery platform based on the previously tested SjCTPI vaccine.

Original language	English
Pages (from-to)	659-668
Number of pages	10
Journal	International Journal for Parasitology
Volume	44
Issue number	9
DOIs	https://doi.org/10.1016/j.ijpara.2014.05.005
Publication status	Published - Aug 2014

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10.1016/j.ijpara.2014.05.005

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Gray, D. J., Li, Y. S., Williams, G. M., Zhao, Z. Y., Harn, D. A., Li, S. M., Ren, M. Y., Feng, Z., Guo, F. Y., Guo, J. G., Zhou, J., Dong, Y. L., Li, Y., Ross, A. G., & McManus, D. P. (2014). A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial. International Journal for Parasitology, 44(9), 659-668. https://doi.org/10.1016/j.ijpara.2014.05.005

@article{7eeaec1b0020489d80a2e58105c90663,

title = "A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial",

abstract = "Despite major successes in its control over the past 50. years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result in new habitats for the oncomelanid intermediate snail host of Schistosoma japonicum (Sj), thereby increasing the risk of transmission. The current national control program for P.R. China involves a multi-component integrated strategy but, despite targeting multiple transmission pathways, certain challenges remain. As the Chinese government pushes towards elimination, there is a requirement for additional tools, such as vaccination, for long-term prevention. Whereas the zoonotic nature of schistosomiasis japonica adds to the complexity of control, it provides a unique opportunity to develop a transmission blocking vaccine targeting bovines to assist in the prevention of human infection and disease. Mathematical modelling has shown that control options targeting the various transmission pathways of schistosomiasis japonica and incorporating bovine vaccination, mass human chemotherapy and mollusciciding could lead to its elimination from P.R. China. Here we present the study design and baseline results of a four-year cluster randomised intervention trial we are undertaking around the schistosomiasis-endemic Dongting Lake in Hunan Province aimed at determining the impact on schistosome transmission of the multi-component integrated control strategy, including bovine vaccination using a heterologous {"}prime-boost{"} delivery platform based on the previously tested SjCTPI vaccine.",

keywords = "China, Cluster-randomised intervention trial, Dongting Lake, Integrated control, Schistosoma japonicum, Schistosomiasis, Schistosomiasis japonica, Transmission blocking vaccine",

author = "Gray, {Darren J.} and Li, {Yue Sheng} and Williams, {Gail M.} and Zhao, {Zheng Yuan} and Harn, {Donald A.} and Li, {Sheng Ming} and Ren, {Mao Yuan} and Zeng Feng and Guo, {Feng Ying} and Guo, {Jia Gang} and Jie Zhou and Dong, {Yu Lan} and Yuan Li and Ross, {Allen G.} and McManus, {Donald P.}",

year = "2014",

month = aug,

doi = "10.1016/j.ijpara.2014.05.005",

language = "English",

volume = "44",

pages = "659--668",

journal = "International Journal for Parasitology",

issn = "0020-7519",

publisher = "Elsevier Ltd.",

number = "9",

}

Gray, DJ, Li, YS, Williams, GM, Zhao, ZY, Harn, DA, Li, SM, Ren, MY, Feng, Z, Guo, FY, Guo, JG, Zhou, J, Dong, YL, Li, Y, Ross, AG & McManus, DP 2014, 'A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial', International Journal for Parasitology, vol. 44, no. 9, pp. 659-668. https://doi.org/10.1016/j.ijpara.2014.05.005

A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial. / Gray, Darren J.; Li, Yue Sheng; Williams, Gail M. et al.
In: International Journal for Parasitology, Vol. 44, No. 9, 08.2014, p. 659-668.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China

T2 - Design and baseline results of a 4-year cluster-randomised intervention trial

AU - Gray, Darren J.

AU - Li, Yue Sheng

AU - Williams, Gail M.

AU - Zhao, Zheng Yuan

AU - Harn, Donald A.

AU - Li, Sheng Ming

AU - Ren, Mao Yuan

AU - Feng, Zeng

AU - Guo, Feng Ying

AU - Guo, Jia Gang

AU - Zhou, Jie

AU - Dong, Yu Lan

AU - Li, Yuan

AU - Ross, Allen G.

AU - McManus, Donald P.

PY - 2014/8

Y1 - 2014/8

N2 - Despite major successes in its control over the past 50. years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result in new habitats for the oncomelanid intermediate snail host of Schistosoma japonicum (Sj), thereby increasing the risk of transmission. The current national control program for P.R. China involves a multi-component integrated strategy but, despite targeting multiple transmission pathways, certain challenges remain. As the Chinese government pushes towards elimination, there is a requirement for additional tools, such as vaccination, for long-term prevention. Whereas the zoonotic nature of schistosomiasis japonica adds to the complexity of control, it provides a unique opportunity to develop a transmission blocking vaccine targeting bovines to assist in the prevention of human infection and disease. Mathematical modelling has shown that control options targeting the various transmission pathways of schistosomiasis japonica and incorporating bovine vaccination, mass human chemotherapy and mollusciciding could lead to its elimination from P.R. China. Here we present the study design and baseline results of a four-year cluster randomised intervention trial we are undertaking around the schistosomiasis-endemic Dongting Lake in Hunan Province aimed at determining the impact on schistosome transmission of the multi-component integrated control strategy, including bovine vaccination using a heterologous "prime-boost" delivery platform based on the previously tested SjCTPI vaccine.

AB - Despite major successes in its control over the past 50. years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result in new habitats for the oncomelanid intermediate snail host of Schistosoma japonicum (Sj), thereby increasing the risk of transmission. The current national control program for P.R. China involves a multi-component integrated strategy but, despite targeting multiple transmission pathways, certain challenges remain. As the Chinese government pushes towards elimination, there is a requirement for additional tools, such as vaccination, for long-term prevention. Whereas the zoonotic nature of schistosomiasis japonica adds to the complexity of control, it provides a unique opportunity to develop a transmission blocking vaccine targeting bovines to assist in the prevention of human infection and disease. Mathematical modelling has shown that control options targeting the various transmission pathways of schistosomiasis japonica and incorporating bovine vaccination, mass human chemotherapy and mollusciciding could lead to its elimination from P.R. China. Here we present the study design and baseline results of a four-year cluster randomised intervention trial we are undertaking around the schistosomiasis-endemic Dongting Lake in Hunan Province aimed at determining the impact on schistosome transmission of the multi-component integrated control strategy, including bovine vaccination using a heterologous "prime-boost" delivery platform based on the previously tested SjCTPI vaccine.

KW - China

KW - Cluster-randomised intervention trial

KW - Dongting Lake

KW - Integrated control

KW - Schistosoma japonicum

KW - Schistosomiasis

KW - Schistosomiasis japonica

KW - Transmission blocking vaccine

UR - http://www.scopus.com/inward/record.url?scp=84904998858&partnerID=8YFLogxK

U2 - 10.1016/j.ijpara.2014.05.005

DO - 10.1016/j.ijpara.2014.05.005

M3 - Article

SN - 0020-7519

VL - 44

SP - 659

EP - 668

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 9

ER -

A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial

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