@article{2c94f01a0d50407e89b4fa7cda21f304,
title = "A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice",
abstract = "Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter and can mediate efficient protection against liver-stage Plasmodium infection. This finding has prompted the development of immunization strategies where T cells are activated in the spleen and then trapped in the liver to form TRM cells. Here, we identify PbRPL6120-127, a H2-Kb-restricted epitope from the putative 60S ribosomal protein L6 (RPL6) of Plasmodium berghei ANKA, as an optimal antigen for endogenous liver TRM cell generation and protection against malaria. A single dose vaccination targeting RPL6 provided effective and prolonged sterilizing immunity against high dose sporozoite challenges. Expressed throughout the parasite life cycle, across Plasmodium species, and highly conserved, RPL6 exhibits strong translation potential as a vaccine candidate. This is further advocated by the identification of a broadly conserved, immunogenic HLA-A∗02:01-restricted epitope in P. falciparum RPL6.",
keywords = "CD8 T cell, T cell memory, adaptive immmunity, antigen, dendritic cell targeting, epitope discovery, liver, malaria, tissue-resident memory T cell, vaccine",
author = "Valencia-Hernandez, {Ana Maria} and Ng, {Wei Yi} and Nazanin Ghazanfari and Sonia Ghilas and {de Menezes}, {Maria N.} and Holz, {Lauren E.} and Cheng Huang and Kieran English and Myo Naung and Tan, {Peck Szee} and Tullett, {Kirsteen M.} and Steiner, {Thiago M.} and Enders, {Matthias H.} and Lynette Beattie and Chua, {Yu Cheng} and Jones, {Claerwen M.} and Anton Cozijnsen and Vanessa Mollard and Yeping Cai and Bowen, {David G.} and Purcell, {Anthony W.} and {La Gruta}, {Nicole L.} and Villadangos, {Jose A.} and {de Koning-Ward}, Tania and Barry, {Alyssa E.} and Winfried Barchet and Cockburn, {Ian A.} and McFadden, {Geoffrey I.} and Stephanie Gras and Lahoud, {Mireille H.} and Patrick Bertolino and Schittenhelm, {Ralf B.} and Irina Caminschi and Heath, {William R.} and Daniel Fernandez-Ruiz",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = jun,
day = "10",
doi = "10.1016/j.chom.2020.04.010",
language = "English",
volume = "27",
pages = "950--962.e7",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "6",
}