A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

Ting T. Cao; Richard H. Thomson; Neil W. Bailey; Nigel C. Rogasch; Rebecca A. Segrave; Jerome J. Maller; Zafiris J. Daskalakis; Paul B. Fitzgerald

doi:10.1016/j.brs.2013.04.006

A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

Ting T. Cao, Richard H. Thomson^*, Neil W. Bailey, Nigel C. Rogasch, Rebecca A. Segrave, Jerome J. Maller, Zafiris J. Daskalakis, Paul B. Fitzgerald

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.

Original language	English
Pages (from-to)	922-924
Number of pages	3
Journal	Brain Stimulation
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/j.brs.2013.04.006
Publication status	Published - Nov 2013
Externally published	Yes

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10.1016/j.brs.2013.04.006

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title = "A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation",

abstract = "High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.",

keywords = "Brain stimulation, Cortical blood flow, Dorsolateral prefrontal cortex, Oxygenated hemoglobin, Transcranial magnetic stimulation",

author = "Cao, {Ting T.} and Thomson, {Richard H.} and Bailey, {Neil W.} and Rogasch, {Nigel C.} and Segrave, {Rebecca A.} and Maller, {Jerome J.} and Daskalakis, {Zafiris J.} and Fitzgerald, {Paul B.}",

year = "2013",

month = nov,

doi = "10.1016/j.brs.2013.04.006",

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journal = "Brain Stimulation",

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AU - Cao, Ting T.

AU - Thomson, Richard H.

AU - Bailey, Neil W.

AU - Rogasch, Nigel C.

AU - Segrave, Rebecca A.

AU - Maller, Jerome J.

AU - Daskalakis, Zafiris J.

AU - Fitzgerald, Paul B.

PY - 2013/11

Y1 - 2013/11

N2 - High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.

AB - High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS.

KW - Brain stimulation

KW - Cortical blood flow

KW - Dorsolateral prefrontal cortex

KW - Oxygenated hemoglobin

KW - Transcranial magnetic stimulation

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DO - 10.1016/j.brs.2013.04.006

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SN - 1935-861X

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SP - 922

EP - 924

JO - Brain Stimulation

JF - Brain Stimulation

IS - 6

ER -

A near infra-red study of blood oxygenation changes resulting from high and low frequency repetitive transcranial magnetic stimulation

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