A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: Synthesis and inhibitory activity

Willard Lew; Huiwei Wu; Dirk B. Mendel; Paul A. Escarpe; Xiaowu Chen; W. Graeme Laver; Bradford J. Graves; Choung U. Kim

doi:10.1016/S0960-894X(98)00587-3

A new series of C₃-aza carbocyclic influenza neuraminidase inhibitors: Synthesis and inhibitory activity

Willard Lew^*, Huiwei Wu, Dirk B. Mendel, Paul A. Escarpe, Xiaowu Chen, W. Graeme Laver, Bradford J. Graves, Choung U. Kim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

The synthesis and influenza neuraminidase inhibitory activity of a new series of C₃-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.

Original language	English
Pages (from-to)	3321-3324
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(98)00587-3
Publication status	Published - 1 Dec 1998

Access to Document

10.1016/S0960-894X(98)00587-3

Cite this

@article{3110b50db5e44b40a81d66bbbdc0a919,

title = "A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: Synthesis and inhibitory activity",

abstract = "The synthesis and influenza neuraminidase inhibitory activity of a new series of C3-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.",

author = "Willard Lew and Huiwei Wu and Mendel, {Dirk B.} and Escarpe, {Paul A.} and Xiaowu Chen and Laver, {W. Graeme} and Graves, {Bradford J.} and Kim, {Choung U.}",

year = "1998",

month = dec,

day = "1",

doi = "10.1016/S0960-894X(98)00587-3",

language = "English",

volume = "8",

pages = "3321--3324",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "23",

}

TY - JOUR

T1 - A new series of C3-aza carbocyclic influenza neuraminidase inhibitors

T2 - Synthesis and inhibitory activity

AU - Lew, Willard

AU - Wu, Huiwei

AU - Mendel, Dirk B.

AU - Escarpe, Paul A.

AU - Chen, Xiaowu

AU - Laver, W. Graeme

AU - Graves, Bradford J.

AU - Kim, Choung U.

PY - 1998/12/1

Y1 - 1998/12/1

N2 - The synthesis and influenza neuraminidase inhibitory activity of a new series of C3-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.

AB - The synthesis and influenza neuraminidase inhibitory activity of a new series of C3-aza carbocyclic neuraminidase inhibitors are described. Analogues 3c and 3j, bearing a 3-pentyl group, exhibit influenza A inhibitory activities comparable to that of 1.

UR - http://www.scopus.com/inward/record.url?scp=0032217040&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(98)00587-3

DO - 10.1016/S0960-894X(98)00587-3

M3 - Article

SN - 0960-894X

VL - 8

SP - 3321

EP - 3324

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

A new series of C₃-aza carbocyclic influenza neuraminidase inhibitors: Synthesis and inhibitory activity

Abstract

Access to Document

Other files and links

Fingerprint

Cite this