A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation

Simon P. Hogan, Anil Mishra, Eric B. Brandt, Michael P. Royalty, Samuel M. Pope, Nives Zimmermann, Paul S. Foster, Marc E. Rothenberg*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    287 Citations (Scopus)

    Abstract

    Although eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been established. Using a murine model of oral antigen-induced eosinophil-associated gastrointestinal disease, we report the pathological consequences of eosinophilic inflammation and the involvement of eotaxin and eosinophils. Exposure of mice to enteric-coated antigen promotes an extensive T helper 2-associated eosinophilic inflammatory response involving the esophagus, stomach, small intestine and Peyer's patches as well as the development of gastric dysmotility, gastromegaly and cachexia. Electron microscopy shows eosinophils in proximity to damaged axons, which indicated that eosinophils were mediating a pathologic response. In addition, mice deficient in eotaxin have impaired eosinophil recruitment and are protected from gastromegaly and cachexia. These results establish a critical pathological function for eotaxin and eosinophils in gastrointestinal allergic hypersensitivity.

    Original languageEnglish
    Pages (from-to)353-360
    Number of pages8
    JournalNature Immunology
    Volume2
    Issue number4
    DOIs
    Publication statusPublished - Apr 2001

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