A pH-driven ring translocation switch against cancer cells

Qian Cheng; Hang Yin; Roselyne Rosas; Didier Gigmes; Olivier Ouari; Ruibing Wang; Anthony Kermagoret; David Bardelang

doi:10.1039/C8CC08681H

A pH-driven ring translocation switch against cancer cells

Qian Cheng, Hang Yin, Roselyne Rosas, Didier Gigmes, Olivier Ouari, Ruibing Wang^*, Anthony Kermagoret, David Bardelang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 10² cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.

Original language	English
Pages (from-to)	13825-13828
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	98
DOIs	https://doi.org/10.1039/C8CC08681H
Publication status	Published - 2018
Externally published	Yes

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10.1039/C8CC08681H

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title = "A pH-driven ring translocation switch against cancer cells",

abstract = "A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 102 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.",

author = "Qian Cheng and Hang Yin and Roselyne Rosas and Didier Gigmes and Olivier Ouari and Ruibing Wang and Anthony Kermagoret and David Bardelang",

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AU - Cheng, Qian

AU - Yin, Hang

AU - Rosas, Roselyne

AU - Gigmes, Didier

AU - Ouari, Olivier

AU - Wang, Ruibing

AU - Kermagoret, Anthony

AU - Bardelang, David

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2018

Y1 - 2018

N2 - A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 102 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.

AB - A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 102 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.

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U2 - 10.1039/C8CC08681H

DO - 10.1039/C8CC08681H

M3 - Article

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AN - SCOPUS:85058096160

SN - 1359-7345

VL - 54

SP - 13825

EP - 13828

JO - Chemical Communications

JF - Chemical Communications

IS - 98

ER -

A pH-driven ring translocation switch against cancer cells

Abstract

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