A platypus' eye view of the mammalian genome

Frank Grützner, Jennifer A.Marshall Graves

    Research output: Contribution to journalReview articlepeer-review

    26 Citations (Scopus)

    Abstract

    The genome of monotremes, like the animals themselves, is unique and strange. The importance of monotremes to genomics depends on their position as the earliest offshoot of the mammalian lineage. Although there has been controversy in the literature over the phylogenetic position of monotremes, this traditional interpretation is now confirmed by recent sequence comparisons. Characterizing the monotreme genome will therefore be important for studying the evolution and organization of the mammalian genome, and the proposal to sequence the platypus genome has been received enthusiastically by the genomics community. Recent investigations of X-chromosome inactivation, genomic imprinting and sex chromosome evolution provide good examples of the power of the monotreme genome to inform us about mammalian genome organization and evolution.

    Original languageEnglish
    Pages (from-to)642-649
    Number of pages8
    JournalCurrent Opinion in Genetics and Development
    Volume14
    Issue number6
    DOIs
    Publication statusPublished - Dec 2004

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