TY - JOUR
T1 - A Portrait of CXCR5+ Follicular Cytotoxic CD8+ T cells
AU - Yu, Di
AU - Ye, Lilin
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/12
Y1 - 2018/12
N2 - CD8+ T cells differentiate into multiple effector and memory subsets to carry out immune clearance of infected and cancerous cells and provide long-term protection. Recent research identified a CXCR5+Tcf1+Tim-3− subset that localizes in, or proximal to, B cell follicles in secondary lymphoid organs of mice, non-human primates, and humans, hereby termed follicular cytotoxic T (TFC) cells. With remarkable similarity to follicular helper T (TFH) cells, TFC differentiation is dependent on transcription factors E2A, Bcl6, and Tcf1, but inhibited by other regulators, including Blimp1, Id2, and Id3. This review summarizes the phenotype, function, and differentiation of this new subset. Owing to its follicular location and self-renewal capability, we propose immunotherapeutic strategies to target TFC cells to potentially treat certain cancers and chronic infections such as HIV-1.
AB - CD8+ T cells differentiate into multiple effector and memory subsets to carry out immune clearance of infected and cancerous cells and provide long-term protection. Recent research identified a CXCR5+Tcf1+Tim-3− subset that localizes in, or proximal to, B cell follicles in secondary lymphoid organs of mice, non-human primates, and humans, hereby termed follicular cytotoxic T (TFC) cells. With remarkable similarity to follicular helper T (TFH) cells, TFC differentiation is dependent on transcription factors E2A, Bcl6, and Tcf1, but inhibited by other regulators, including Blimp1, Id2, and Id3. This review summarizes the phenotype, function, and differentiation of this new subset. Owing to its follicular location and self-renewal capability, we propose immunotherapeutic strategies to target TFC cells to potentially treat certain cancers and chronic infections such as HIV-1.
UR - http://www.scopus.com/inward/record.url?scp=85055449628&partnerID=8YFLogxK
U2 - 10.1016/j.it.2018.10.002
DO - 10.1016/j.it.2018.10.002
M3 - Review article
SN - 1471-4906
VL - 39
SP - 965
EP - 979
JO - Trends in Immunology
JF - Trends in Immunology
IS - 12
ER -