A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study

Prue H. Hart; Anderson P. Jones; Stephanie Trend; Lilian Cha; Marzena J. Fabis-Pedrini; Matthew N. Cooper; Catherine d’Este; Sian Geldenhuys; William M. Carroll; Scott N. Byrne; David R. Booth; Judith M. Cole; Robyn M. Lucas; Allan G. Kermode

doi:10.1177/2055217318773112

A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study

Prue H. Hart^*, Anderson P. Jones, Stephanie Trend, Lilian Cha, Marzena J. Fabis-Pedrini, Matthew N. Cooper, Catherine d’Este, Sian Geldenhuys, William M. Carroll, Scott N. Byrne, David R. Booth, Judith M. Cole, Robyn M. Lucas, Allan G. Kermode

^*Corresponding author for this work

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Abstract

Background: The natural history of multiple sclerosis (MS) typically presents with the clinically isolated syndrome (CIS), an episode of neurological symptoms caused by central nervous system inflammation or demyelination that does not fulfil the diagnostic criteria for MS. Objective: As preclinical studies have suggested that exposure to ultraviolet radiation (UVR) could regulate the development of MS, the Phototherapy for CIS (PhoCIS trial) was established to examine the effects of narrowband UVB phototherapy on patients with CIS, and their conversion to MS. Methods: Of the 20 participants, half received 24 sessions of narrowband UVB exposure over eight weeks; participants in both arms were followed for 12 months. All participants were supplemented to 25-hydroxyvitamin D₃ levels of >80 nmol/l. Results: By 12 months, 100% of those in the no phototherapy arm and 70% in the phototherapy arm had converted to MS, although this difference was not statistically significant. Conclusion: This study provides a basis for further studies to determine if there are any benefits of the therapeutic effects of narrowband UVB radiation on MS progression.

Original language	English
Journal	Multiple Sclerosis Journal - Experimental, Translational and Clinical
Volume	4
Issue number	2
DOIs	https://doi.org/10.1177/2055217318773112
Publication status	Published - 1 Apr 2018

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Hart, P. H., Jones, A. P., Trend, S., Cha, L., Fabis-Pedrini, M. J., Cooper, M. N., d’Este, C., Geldenhuys, S., Carroll, W. M., Byrne, S. N., Booth, D. R., Cole, J. M., Lucas, R. M., & Kermode, A. G. (2018). A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 4(2). https://doi.org/10.1177/2055217318773112

@article{1a57d7f7ccc04b11b236ba689158777c,

title = "A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study",

abstract = "Background: The natural history of multiple sclerosis (MS) typically presents with the clinically isolated syndrome (CIS), an episode of neurological symptoms caused by central nervous system inflammation or demyelination that does not fulfil the diagnostic criteria for MS. Objective: As preclinical studies have suggested that exposure to ultraviolet radiation (UVR) could regulate the development of MS, the Phototherapy for CIS (PhoCIS trial) was established to examine the effects of narrowband UVB phototherapy on patients with CIS, and their conversion to MS. Methods: Of the 20 participants, half received 24 sessions of narrowband UVB exposure over eight weeks; participants in both arms were followed for 12 months. All participants were supplemented to 25-hydroxyvitamin D3 levels of >80 nmol/l. Results: By 12 months, 100% of those in the no phototherapy arm and 70% in the phototherapy arm had converted to MS, although this difference was not statistically significant. Conclusion: This study provides a basis for further studies to determine if there are any benefits of the therapeutic effects of narrowband UVB radiation on MS progression.",

keywords = "Narrowband UVB phototherapy, UV-induced immunosuppression, clinically isolated syndrome, trial, vitamin D supplementation",

author = "Hart, {Prue H.} and Jones, {Anderson P.} and Stephanie Trend and Lilian Cha and Fabis-Pedrini, {Marzena J.} and Cooper, {Matthew N.} and Catherine d{\textquoteright}Este and Sian Geldenhuys and Carroll, {William M.} and Byrne, {Scott N.} and Booth, {David R.} and Cole, {Judith M.} and Lucas, {Robyn M.} and Kermode, {Allan G.}",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s) 2018.",

year = "2018",

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day = "1",

doi = "10.1177/2055217318773112",

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volume = "4",

journal = "Multiple Sclerosis Journal - Experimental, Translational and Clinical",

issn = "2055-2173",

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Hart, PH, Jones, AP, Trend, S, Cha, L, Fabis-Pedrini, MJ, Cooper, MN, d’Este, C, Geldenhuys, S, Carroll, WM, Byrne, SN, Booth, DR, Cole, JM, Lucas, RM & Kermode, AG 2018, 'A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study', Multiple Sclerosis Journal - Experimental, Translational and Clinical, vol. 4, no. 2. https://doi.org/10.1177/2055217318773112

TY - JOUR

T1 - A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome

T2 - The PhoCIS study

AU - Hart, Prue H.

AU - Jones, Anderson P.

AU - Trend, Stephanie

AU - Cha, Lilian

AU - Fabis-Pedrini, Marzena J.

AU - Cooper, Matthew N.

AU - d’Este, Catherine

AU - Geldenhuys, Sian

AU - Carroll, William M.

AU - Byrne, Scott N.

AU - Booth, David R.

AU - Cole, Judith M.

AU - Lucas, Robyn M.

AU - Kermode, Allan G.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: The natural history of multiple sclerosis (MS) typically presents with the clinically isolated syndrome (CIS), an episode of neurological symptoms caused by central nervous system inflammation or demyelination that does not fulfil the diagnostic criteria for MS. Objective: As preclinical studies have suggested that exposure to ultraviolet radiation (UVR) could regulate the development of MS, the Phototherapy for CIS (PhoCIS trial) was established to examine the effects of narrowband UVB phototherapy on patients with CIS, and their conversion to MS. Methods: Of the 20 participants, half received 24 sessions of narrowband UVB exposure over eight weeks; participants in both arms were followed for 12 months. All participants were supplemented to 25-hydroxyvitamin D3 levels of >80 nmol/l. Results: By 12 months, 100% of those in the no phototherapy arm and 70% in the phototherapy arm had converted to MS, although this difference was not statistically significant. Conclusion: This study provides a basis for further studies to determine if there are any benefits of the therapeutic effects of narrowband UVB radiation on MS progression.

AB - Background: The natural history of multiple sclerosis (MS) typically presents with the clinically isolated syndrome (CIS), an episode of neurological symptoms caused by central nervous system inflammation or demyelination that does not fulfil the diagnostic criteria for MS. Objective: As preclinical studies have suggested that exposure to ultraviolet radiation (UVR) could regulate the development of MS, the Phototherapy for CIS (PhoCIS trial) was established to examine the effects of narrowband UVB phototherapy on patients with CIS, and their conversion to MS. Methods: Of the 20 participants, half received 24 sessions of narrowband UVB exposure over eight weeks; participants in both arms were followed for 12 months. All participants were supplemented to 25-hydroxyvitamin D3 levels of >80 nmol/l. Results: By 12 months, 100% of those in the no phototherapy arm and 70% in the phototherapy arm had converted to MS, although this difference was not statistically significant. Conclusion: This study provides a basis for further studies to determine if there are any benefits of the therapeutic effects of narrowband UVB radiation on MS progression.

KW - Narrowband UVB phototherapy

KW - UV-induced immunosuppression

KW - clinically isolated syndrome

KW - trial

KW - vitamin D supplementation

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U2 - 10.1177/2055217318773112

DO - 10.1177/2055217318773112

M3 - Article

SN - 2055-2173

VL - 4

JO - Multiple Sclerosis Journal - Experimental, Translational and Clinical

JF - Multiple Sclerosis Journal - Experimental, Translational and Clinical

IS - 2

ER -

A randomised, controlled clinical trial of narrowband UVB phototherapy for clinically isolated syndrome: The PhoCIS study

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