A role for eosinophils in airway remodelling in asthma

A. Barry Kay, Simon Phipps, Douglas S. Robinson

    Research output: Contribution to journalArticlepeer-review

    268 Citations (Scopus)

    Abstract

    Over the years, the role of the eosinophil in asthma and allergic processes has been disputed. Recent human experiments using a humanised monoclonal antibody to interleukin-5 (IL-5), and animal studies involving specific IL-5 gene deletion, indicates that eosinophils might control downstream repair and remodelling processes. Eosinophils are a rich source of fibrogenic factors, particularly transforming growth factor-β (TGF-β), the latent form of which is activated by epithelial-cell expression of the intergin αvβ6. The emerging role for the eosinophil in airway remodelling might be important in future anti-asthma strategies. However, more effective eosinophil-depleting agents than anti-IL-5 are required before the definitive role of this cell type in asthma airway pathophysiology can be established.

    Original languageEnglish
    Pages (from-to)477-482
    Number of pages6
    JournalTrends in Immunology
    Volume25
    Issue number9
    DOIs
    Publication statusPublished - Sept 2004

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