A role for glutathione transferase omega 1 (GSTO1-1) in the glutathionylation cycle

Deepthi Menon; Philip G. Board

doi:10.1074/jbc.M113.487785

A role for glutathione transferase omega 1 (GSTO1-1) in the glutathionylation cycle

Deepthi Menon
, Philip G. Board^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

128 Citations (Scopus)

Abstract

Background: Glutathionylation is a major post-translational modification that regulates protein function. Results: Human glutathione transferase Omega 1 (GSTO1-1) can catalyze the deglutathionylation of protein thiols in vitro and in cell culture. Conclusion: GSTO1-1, but not GSTO2-2, catalyzes the deglutathionylation of actin and other proteins under physiological conditions. Significance: Genetic variation in GSTO1-1-catalyzed deglutathionylation may influence the function of multiple proteins in signaling pathways.

Original language	English
Pages (from-to)	25769-25779
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.487785
Publication status	Published - 6 Sept 2013

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abstract = "Background: Glutathionylation is a major post-translational modification that regulates protein function. Results: Human glutathione transferase Omega 1 (GSTO1-1) can catalyze the deglutathionylation of protein thiols in vitro and in cell culture. Conclusion: GSTO1-1, but not GSTO2-2, catalyzes the deglutathionylation of actin and other proteins under physiological conditions. Significance: Genetic variation in GSTO1-1-catalyzed deglutathionylation may influence the function of multiple proteins in signaling pathways.",

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AU - Board, Philip G.

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N2 - Background: Glutathionylation is a major post-translational modification that regulates protein function. Results: Human glutathione transferase Omega 1 (GSTO1-1) can catalyze the deglutathionylation of protein thiols in vitro and in cell culture. Conclusion: GSTO1-1, but not GSTO2-2, catalyzes the deglutathionylation of actin and other proteins under physiological conditions. Significance: Genetic variation in GSTO1-1-catalyzed deglutathionylation may influence the function of multiple proteins in signaling pathways.

AB - Background: Glutathionylation is a major post-translational modification that regulates protein function. Results: Human glutathione transferase Omega 1 (GSTO1-1) can catalyze the deglutathionylation of protein thiols in vitro and in cell culture. Conclusion: GSTO1-1, but not GSTO2-2, catalyzes the deglutathionylation of actin and other proteins under physiological conditions. Significance: Genetic variation in GSTO1-1-catalyzed deglutathionylation may influence the function of multiple proteins in signaling pathways.

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DO - 10.1074/jbc.M113.487785

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EP - 25779

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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ER -

A role for glutathione transferase omega 1 (GSTO1-1) in the glutathionylation cycle

Abstract

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