A Second Wave for the Neurokinin Tac2 Pathway in Brain Research

A. Shaam Al Abed, Nathan J. Reynolds, Nathalie Dehorter*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    6 Citations (Scopus)

    Abstract

    Despite promising advances in basic research of the neurokinin B/Tac2 pathway in both animals and humans, clinical applications are yet to be implemented. This is likely because of our limited understanding of the action of the pathway in the brain. While this system controls neuronal activity in multiple regions, the precise impact of Tac2-induced cellular responses on behavior remains unclear. Recently, elegant studies revealed a key contribution to stress-related behaviors and memory. Here, we discuss the crucial importance of bridging the gap between the Tac2 pathway's involvement in cell physiology and cognition to comprehend its role in health and disease. We propose that a better understanding of the Tac2 pathway in the brain could provide an essential perspective for basic investigations, which in turn will feed clinical research.

    Original languageEnglish
    Pages (from-to)156-164
    Number of pages9
    JournalBiological Psychiatry
    Volume90
    Issue number3
    DOIs
    Publication statusPublished - 1 Aug 2021

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