A theoretical study of bone remodelling under PEMF at cellular level

Yanan Wang; Qing Hua Qin

doi:10.1080/10255842.2011.565752

A theoretical study of bone remodelling under PEMF at cellular level

Yanan Wang, Qing Hua Qin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Pulsed electromagnetic field (PEMF) devices have been used clinically to slow down osteoporosis and accelerate the healing of bone fractures for many years. However, the underlying mechanism by which bone remodelling under PEMF is regulated remains poorly understood. In this paper, a mathematical model of bone cell population of bone remodelling under PEMF at cellular level is developed to address this issue for the first time. On the basis of this model and control theory, parametric study of control mechanisms is carried out and a number of possible control mechanisms are identified. These findings will help further the understanding of bone remodelling under PEMF and advance therapies and pharmacological developments in clinical trials.

Original language	English
Pages (from-to)	885-897
Number of pages	13
Journal	Computer Methods in Biomechanics and Biomedical Engineering
Volume	15
Issue number	8
DOIs	https://doi.org/10.1080/10255842.2011.565752
Publication status	Published - Aug 2012

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10.1080/10255842.2011.565752

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AB - Pulsed electromagnetic field (PEMF) devices have been used clinically to slow down osteoporosis and accelerate the healing of bone fractures for many years. However, the underlying mechanism by which bone remodelling under PEMF is regulated remains poorly understood. In this paper, a mathematical model of bone cell population of bone remodelling under PEMF at cellular level is developed to address this issue for the first time. On the basis of this model and control theory, parametric study of control mechanisms is carried out and a number of possible control mechanisms are identified. These findings will help further the understanding of bone remodelling under PEMF and advance therapies and pharmacological developments in clinical trials.

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A theoretical study of bone remodelling under PEMF at cellular level

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