A Versatile and Scalable Strategy to Discrete Oligomers

Jimmy Lawrence; Sang Ho Lee; Allison Abdilla; Mitchell D. Nothling; Jing M. Ren; Abigail S. Knight; Carolin Fleischmann; Youli Li; Austin S. Abrams; Bernhard V.K.J. Schmidt; Michael C. Hawker; Luke A. Connal; Alaina J. McGrath; Paul G. Clark; Will R. Gutekunst; Craig J. Hawker

doi:10.1021/jacs.6b03127

A Versatile and Scalable Strategy to Discrete Oligomers

Jimmy Lawrence, Sang Ho Lee, Allison Abdilla, Mitchell D. Nothling, Jing M. Ren, Abigail S. Knight, Carolin Fleischmann, Youli Li, Austin S. Abrams, Bernhard V.K.J. Schmidt, Michael C. Hawker, Luke A. Connal, Alaina J. McGrath, Paul G. Clark, Will R. Gutekunst^*, Craig J. Hawker

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

A versatile strategy is reported for the multigram synthesis of discrete oligomers from commercially available monomer families, e.g., acrylates, styrenics, and siloxanes. Central to this strategy is the identification of reproducible procedures for the separation of oligomer mixtures using automated flash chromatography systems with the effectiveness of this approach demonstrated through the multigram preparation of discrete oligomer libraries (= 1.0). Synthetic availability, coupled with accurate structural control, allows these functional building blocks to be harnessed for both fundamental studies as well as targeted technological applications.

Original language	English
Pages (from-to)	6306-6310
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	138
Issue number	19
DOIs	https://doi.org/10.1021/jacs.6b03127
Publication status	Published - 18 May 2016
Externally published	Yes

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Lawrence, J., Lee, S. H., Abdilla, A., Nothling, M. D., Ren, J. M., Knight, A. S., Fleischmann, C., Li, Y., Abrams, A. S., Schmidt, B. V. K. J., Hawker, M. C., Connal, L. A., McGrath, A. J., Clark, P. G., Gutekunst, W. R., & Hawker, C. J. (2016). A Versatile and Scalable Strategy to Discrete Oligomers. Journal of the American Chemical Society, 138(19), 6306-6310. https://doi.org/10.1021/jacs.6b03127

@article{81d4047e01f3445daef76268e6b90e83,

title = "A Versatile and Scalable Strategy to Discrete Oligomers",

abstract = "A versatile strategy is reported for the multigram synthesis of discrete oligomers from commercially available monomer families, e.g., acrylates, styrenics, and siloxanes. Central to this strategy is the identification of reproducible procedures for the separation of oligomer mixtures using automated flash chromatography systems with the effectiveness of this approach demonstrated through the multigram preparation of discrete oligomer libraries (= 1.0). Synthetic availability, coupled with accurate structural control, allows these functional building blocks to be harnessed for both fundamental studies as well as targeted technological applications.",

author = "Jimmy Lawrence and Lee, {Sang Ho} and Allison Abdilla and Nothling, {Mitchell D.} and Ren, {Jing M.} and Knight, {Abigail S.} and Carolin Fleischmann and Youli Li and Abrams, {Austin S.} and Schmidt, {Bernhard V.K.J.} and Hawker, {Michael C.} and Connal, {Luke A.} and McGrath, {Alaina J.} and Clark, {Paul G.} and Gutekunst, {Will R.} and Hawker, {Craig J.}",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

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language = "English",

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Lawrence, J, Lee, SH, Abdilla, A, Nothling, MD, Ren, JM, Knight, AS, Fleischmann, C, Li, Y, Abrams, AS, Schmidt, BVKJ, Hawker, MC, Connal, LA, McGrath, AJ, Clark, PG, Gutekunst, WR & Hawker, CJ 2016, 'A Versatile and Scalable Strategy to Discrete Oligomers', Journal of the American Chemical Society, vol. 138, no. 19, pp. 6306-6310. https://doi.org/10.1021/jacs.6b03127

TY - JOUR

T1 - A Versatile and Scalable Strategy to Discrete Oligomers

AU - Lawrence, Jimmy

AU - Lee, Sang Ho

AU - Abdilla, Allison

AU - Nothling, Mitchell D.

AU - Ren, Jing M.

AU - Knight, Abigail S.

AU - Fleischmann, Carolin

AU - Li, Youli

AU - Abrams, Austin S.

AU - Schmidt, Bernhard V.K.J.

AU - Hawker, Michael C.

AU - Connal, Luke A.

AU - McGrath, Alaina J.

AU - Clark, Paul G.

AU - Gutekunst, Will R.

AU - Hawker, Craig J.

PY - 2016/5/18

Y1 - 2016/5/18

N2 - A versatile strategy is reported for the multigram synthesis of discrete oligomers from commercially available monomer families, e.g., acrylates, styrenics, and siloxanes. Central to this strategy is the identification of reproducible procedures for the separation of oligomer mixtures using automated flash chromatography systems with the effectiveness of this approach demonstrated through the multigram preparation of discrete oligomer libraries (= 1.0). Synthetic availability, coupled with accurate structural control, allows these functional building blocks to be harnessed for both fundamental studies as well as targeted technological applications.

AB - A versatile strategy is reported for the multigram synthesis of discrete oligomers from commercially available monomer families, e.g., acrylates, styrenics, and siloxanes. Central to this strategy is the identification of reproducible procedures for the separation of oligomer mixtures using automated flash chromatography systems with the effectiveness of this approach demonstrated through the multigram preparation of discrete oligomer libraries (= 1.0). Synthetic availability, coupled with accurate structural control, allows these functional building blocks to be harnessed for both fundamental studies as well as targeted technological applications.

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U2 - 10.1021/jacs.6b03127

DO - 10.1021/jacs.6b03127

M3 - Article

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VL - 138

SP - 6306

EP - 6310

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 19

ER -

A Versatile and Scalable Strategy to Discrete Oligomers

Abstract

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