TY - JOUR
T1 - Adaptable and Multifunctional Ion-Conducting Aquaporins
AU - Tyerman, Stephen D.
AU - McGaughey, Samantha A.
AU - Qiu, Jiaen
AU - Yool, Andrea J.
AU - Byrt, Caitlin S.
N1 - Publisher Copyright:
© 2021 Annual Reviews Inc.. All rights reserved.
PY - 2021/6/17
Y1 - 2021/6/17
N2 - Aquaporins function as water and neutral solute channels, signaling hubs, disease virulence factors, and metabolon components. We consider plant aquaporins that transport ions compared to some animal counterparts. These are candidates for important, as yet unidentified, cation and anion channels in plasma, tonoplast, and symbiotic membranes. For those individual isoforms that transport ions, water, and gases, the permeability spans 12 orders of magnitude. This requires tight regulation of selectivity via protein interactions and posttranslational modifications. A phosphorylation-dependent switch between ion and water permeation in AtPIP2;1 might be explained by coupling between the gates of the four monomer water channels and the central pore of the tetramer. We consider the potential for coupling between ion and water fluxes that could form the basis of an electroosmotic transducer. A grand challenge in understanding the roles of ion transporting aquaporins is their multifunctional modes that are dependent on location, stress, time, and development.
AB - Aquaporins function as water and neutral solute channels, signaling hubs, disease virulence factors, and metabolon components. We consider plant aquaporins that transport ions compared to some animal counterparts. These are candidates for important, as yet unidentified, cation and anion channels in plasma, tonoplast, and symbiotic membranes. For those individual isoforms that transport ions, water, and gases, the permeability spans 12 orders of magnitude. This requires tight regulation of selectivity via protein interactions and posttranslational modifications. A phosphorylation-dependent switch between ion and water permeation in AtPIP2;1 might be explained by coupling between the gates of the four monomer water channels and the central pore of the tetramer. We consider the potential for coupling between ion and water fluxes that could form the basis of an electroosmotic transducer. A grand challenge in understanding the roles of ion transporting aquaporins is their multifunctional modes that are dependent on location, stress, time, and development.
KW - anion channel
KW - channel gating
KW - electroosmosis
KW - ion channel
KW - nonselective cation channel
KW - water pumping
UR - http://www.scopus.com/inward/record.url?scp=85107692950&partnerID=8YFLogxK
U2 - 10.1146/annurev-arplant-081720-013608
DO - 10.1146/annurev-arplant-081720-013608
M3 - Review article
SN - 1543-5008
VL - 72
SP - 703
EP - 736
JO - Annual Review of Plant Biology
JF - Annual Review of Plant Biology
ER -