Adaptive 2DCCA based approach for improving spatial specificity of activation detection in functional MRI

Muhammad Usman Khalid*, Adnan Shah, Abd Krim Seghouane

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    9 Citations (Scopus)

    Abstract

    The univariate approach without a smoothing filter for detecting activation patterns in functional magnetic resonance imaging (fMRI) data suffers from a low sensitivity due to presence of high noise. The poor performance of univariate methods such as ordinary correlation is due to lack of their ability to take advantage of spatial correlation that exists in fMR images among group of neighboring voxels. To rectify this problem multivariate approaches such as canonical correlation analysis (CCA), adaptive canonical correlation analysis (ACCA) and spatial Gaussian smoothing accompanied with univariate correlation has already been applied to fMR images to improve both sensitivity and specificity. In this work idea of smoothing fMR images with ACCA has been extended to adaptive two-dimensional canonical correlation analysis (A2DCCA) to obtain improvements in detection performance in terms of specificity. It is shown on synthetic and real fMRI data that A2DCCA produces better specificity than ACCA and Gaussian smoothing.

    Original languageEnglish
    Title of host publication2012 International Conference on Digital Image Computing Techniques and Applications, DICTA 2012
    DOIs
    Publication statusPublished - 2012
    Event2012 14th International Conference on Digital Image Computing Techniques and Applications, DICTA 2012 - Fremantle, WA, Australia
    Duration: 3 Dec 20125 Dec 2012

    Publication series

    Name2012 International Conference on Digital Image Computing Techniques and Applications, DICTA 2012

    Conference

    Conference2012 14th International Conference on Digital Image Computing Techniques and Applications, DICTA 2012
    Country/TerritoryAustralia
    CityFremantle, WA
    Period3/12/125/12/12

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