TY - JOUR
T1 - Agreement between general practice prescription data and self-reported use of hormone replacement therapy and treatment for various illnesses
AU - Banks, E.
AU - Beral, V.
AU - Cameron, R.
AU - Hogg, A.
AU - Langley, N.
AU - Barnes, I.
AU - Bull, D.
AU - Elliman, J.
AU - Harris, C. L.
PY - 2001
Y1 - 2001
N2 - Background. Epidemiological studies of the effects of hormone replacement therapy (HRT) often rely on exposure data and information on past health from self-administered questionnaires. The accuracy with which women report current use of HRT and the specific preparation in use is not known. This study aims to compare aspects of self-reported use of HRT and treatment for various conditions with data from general practice prescription records. Methods. Reported questionnaire data on use of HRT were compared with those on the general practice prescription record for 570 women participating in the Million Women Study from two general practices in the UK. Results. There was excellent agreement between data from the self-administered questionnaire and the prescription record: 96% agreement (κ = 0.91) for current use of HRT, 95% agreement (κ = 0.90) for any use of HRT during the period covered by the prescription record, and 97% agreement (κ = 0.95) among current users for whether the HRT preparation contained oestrogen alone, combined oestrogen/progestogen, or some other constituents. Among former HRT users who provided questionnaire information on the preparation they used most recently, there was 69% agreement on the proprietary preparation used and 97% agreement (κ = 0.93) on the hormonal constituents used. Agreement between reported treatment for various conditions and the presence of a prescription appropriate for that condition ranged from 89-99% (κ 0.53-0.92), and was highest for thyroid disease and asthma. Conclusion. Important aspects of use of HRT, such as type of preparation currently being used, are reported very reliably by women completing a self-administered questionnaire.
AB - Background. Epidemiological studies of the effects of hormone replacement therapy (HRT) often rely on exposure data and information on past health from self-administered questionnaires. The accuracy with which women report current use of HRT and the specific preparation in use is not known. This study aims to compare aspects of self-reported use of HRT and treatment for various conditions with data from general practice prescription records. Methods. Reported questionnaire data on use of HRT were compared with those on the general practice prescription record for 570 women participating in the Million Women Study from two general practices in the UK. Results. There was excellent agreement between data from the self-administered questionnaire and the prescription record: 96% agreement (κ = 0.91) for current use of HRT, 95% agreement (κ = 0.90) for any use of HRT during the period covered by the prescription record, and 97% agreement (κ = 0.95) among current users for whether the HRT preparation contained oestrogen alone, combined oestrogen/progestogen, or some other constituents. Among former HRT users who provided questionnaire information on the preparation they used most recently, there was 69% agreement on the proprietary preparation used and 97% agreement (κ = 0.93) on the hormonal constituents used. Agreement between reported treatment for various conditions and the presence of a prescription appropriate for that condition ranged from 89-99% (κ 0.53-0.92), and was highest for thyroid disease and asthma. Conclusion. Important aspects of use of HRT, such as type of preparation currently being used, are reported very reliably by women completing a self-administered questionnaire.
KW - Agreement
KW - Hormone replacement therapy
KW - The Million Women Study
KW - Validation
UR - http://www.scopus.com/inward/record.url?scp=0035208049&partnerID=8YFLogxK
U2 - 10.1080/13595220152601837
DO - 10.1080/13595220152601837
M3 - Article
SN - 1359-5229
VL - 6
SP - 357
EP - 363
JO - Journal of Epidemiology and Biostatistics
JF - Journal of Epidemiology and Biostatistics
IS - 4
ER -