Alkylations and hydroxymethylations of pyrazines via green minisci-type reactions

Bjorn Bohman; Benjamin Berntsson; Ruby C.M. Dixon; Craig D. Stewart; Russell A. Barrow

doi:10.1021/ol500776j

Alkylations and hydroxymethylations of pyrazines via green minisci-type reactions

Bjorn Bohman, Benjamin Berntsson, Ruby C.M. Dixon, Craig D. Stewart, Russell A. Barrow^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl) pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones.

Original language	English
Pages (from-to)	2787-2789
Number of pages	3
Journal	Organic Letters
Volume	16
Issue number	11
DOIs	https://doi.org/10.1021/ol500776j
Publication status	Published - 6 Jun 2014

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title = "Alkylations and hydroxymethylations of pyrazines via green minisci-type reactions",

abstract = "A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl) pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones.",

author = "Bjorn Bohman and Benjamin Berntsson and Dixon, {Ruby C.M.} and Stewart, {Craig D.} and Barrow, {Russell A.}",

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AU - Bohman, Bjorn

AU - Berntsson, Benjamin

AU - Dixon, Ruby C.M.

AU - Stewart, Craig D.

AU - Barrow, Russell A.

PY - 2014/6/6

Y1 - 2014/6/6

N2 - A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl) pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones.

AB - A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl) pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones.

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U2 - 10.1021/ol500776j

DO - 10.1021/ol500776j

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JO - Organic Letters

JF - Organic Letters

IS - 11

ER -

Alkylations and hydroxymethylations of pyrazines via green minisci-type reactions

Abstract

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