Alpha class glutathione transferase polymorphisms identified by EST database analysis

Natasha L. Tetlow; Anneke C. Blackburn; Gareth Chelvanayagam; Philip G. Board

Alpha class glutathione transferase polymorphisms identified by EST database analysis

Natasha L. Tetlow, Anneke C. Blackburn, Gareth Chelvanayagam, Philip G. Board^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Polymorphisms in the mu, pi and theta class glutathione transferase (GST) genes have been implicated in susceptibility to a number of diseases. New polymorphisms can be identified by searching the expressed sequence tag (EST) database, as it contains a multitude of sequences collected from many individuals. The EST database was used to search for polymorphisms in the GST alpha class genes. The presence of confirmed polymorphisms in three different ethnic groups has been examined, and the recombinant proteins expressed in Escherichia coli for further study.

Original language	English
Pages (from-to)	123-125
Number of pages	3
Journal	Chemico-Biological Interactions
Volume	133
Issue number	1-3
Publication status	Published - 28 Feb 2001

Cite this

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abstract = "Polymorphisms in the mu, pi and theta class glutathione transferase (GST) genes have been implicated in susceptibility to a number of diseases. New polymorphisms can be identified by searching the expressed sequence tag (EST) database, as it contains a multitude of sequences collected from many individuals. The EST database was used to search for polymorphisms in the GST alpha class genes. The presence of confirmed polymorphisms in three different ethnic groups has been examined, and the recombinant proteins expressed in Escherichia coli for further study.",

keywords = "Database analysis, EST database, Glutathione transferase, Polymorphism",

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AU - Tetlow, Natasha L.

AU - Blackburn, Anneke C.

AU - Chelvanayagam, Gareth

AU - Board, Philip G.

PY - 2001/2/28

Y1 - 2001/2/28

N2 - Polymorphisms in the mu, pi and theta class glutathione transferase (GST) genes have been implicated in susceptibility to a number of diseases. New polymorphisms can be identified by searching the expressed sequence tag (EST) database, as it contains a multitude of sequences collected from many individuals. The EST database was used to search for polymorphisms in the GST alpha class genes. The presence of confirmed polymorphisms in three different ethnic groups has been examined, and the recombinant proteins expressed in Escherichia coli for further study.

AB - Polymorphisms in the mu, pi and theta class glutathione transferase (GST) genes have been implicated in susceptibility to a number of diseases. New polymorphisms can be identified by searching the expressed sequence tag (EST) database, as it contains a multitude of sequences collected from many individuals. The EST database was used to search for polymorphisms in the GST alpha class genes. The presence of confirmed polymorphisms in three different ethnic groups has been examined, and the recombinant proteins expressed in Escherichia coli for further study.

KW - Database analysis

KW - EST database

KW - Glutathione transferase

KW - Polymorphism

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JO - Chemico-Biological Interactions

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ER -

Alpha class glutathione transferase polymorphisms identified by EST database analysis

Abstract

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