Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in nondemented older adults

G. Peggy McFall; Sandra A. Wiebe; David Vergote; Kaarin J. Anstey; Roger A. Dixon

doi:10.1016/j.dadm.2015.08.002

Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in nondemented older adults

G. Peggy McFall, Sandra A. Wiebe, David Vergote, Kaarin J. Anstey, Roger A. Dixon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Introduction: We examine interactive and intensification effects of type 2 diabetes (T2D) with APOE and an Alzheimer's disease genetic risk score (GRS) on neurocognitive speed performance and change in nondemented older adults. Methods: In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline median age = 69.0) followed over 9 years. The GRS was compiled using the cumulative risk of APOE, CLU, CR1, and PICALM. Results: First, T2D predicted slower speed performance at centering age (75). Second, no predictive effects were associated with APOE or GRS. Third, a significant interaction showed that high risk from both T2D and GRS was selectively associated with steeper longitudinal slowing than all comparison cross-domain risk groups. Discussion: Higher AD-related genetic risk intensified deleterious effects of diabetes on neurocognitive slowing in nondemented aging beyond the independent influence of APOE.

Original language	English
Pages (from-to)	395-402
Number of pages	8
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/j.dadm.2015.08.002
Publication status	Published - 1 Dec 2015

Access to Document

10.1016/j.dadm.2015.08.002

Cite this

@article{7318d35829c84b6b9542b76983b698d9,

title = "Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in nondemented older adults",

abstract = "Introduction: We examine interactive and intensification effects of type 2 diabetes (T2D) with APOE and an Alzheimer's disease genetic risk score (GRS) on neurocognitive speed performance and change in nondemented older adults. Methods: In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline median age = 69.0) followed over 9 years. The GRS was compiled using the cumulative risk of APOE, CLU, CR1, and PICALM. Results: First, T2D predicted slower speed performance at centering age (75). Second, no predictive effects were associated with APOE or GRS. Third, a significant interaction showed that high risk from both T2D and GRS was selectively associated with steeper longitudinal slowing than all comparison cross-domain risk groups. Discussion: Higher AD-related genetic risk intensified deleterious effects of diabetes on neurocognitive slowing in nondemented aging beyond the independent influence of APOE.",

keywords = "APOE, Alzheimer's disease genetic risk score, Neurocognitive speed, Type 2 diabetes, Victoria longitudinal study",

author = "McFall, {G. Peggy} and Wiebe, {Sandra A.} and David Vergote and Anstey, {Kaarin J.} and Dixon, {Roger A.}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.dadm.2015.08.002",

language = "English",

volume = "1",

pages = "395--402",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

publisher = "John Wiley & Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in nondemented older adults

AU - McFall, G. Peggy

AU - Wiebe, Sandra A.

AU - Vergote, David

AU - Anstey, Kaarin J.

AU - Dixon, Roger A.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Introduction: We examine interactive and intensification effects of type 2 diabetes (T2D) with APOE and an Alzheimer's disease genetic risk score (GRS) on neurocognitive speed performance and change in nondemented older adults. Methods: In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline median age = 69.0) followed over 9 years. The GRS was compiled using the cumulative risk of APOE, CLU, CR1, and PICALM. Results: First, T2D predicted slower speed performance at centering age (75). Second, no predictive effects were associated with APOE or GRS. Third, a significant interaction showed that high risk from both T2D and GRS was selectively associated with steeper longitudinal slowing than all comparison cross-domain risk groups. Discussion: Higher AD-related genetic risk intensified deleterious effects of diabetes on neurocognitive slowing in nondemented aging beyond the independent influence of APOE.

AB - Introduction: We examine interactive and intensification effects of type 2 diabetes (T2D) with APOE and an Alzheimer's disease genetic risk score (GRS) on neurocognitive speed performance and change in nondemented older adults. Methods: In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline median age = 69.0) followed over 9 years. The GRS was compiled using the cumulative risk of APOE, CLU, CR1, and PICALM. Results: First, T2D predicted slower speed performance at centering age (75). Second, no predictive effects were associated with APOE or GRS. Third, a significant interaction showed that high risk from both T2D and GRS was selectively associated with steeper longitudinal slowing than all comparison cross-domain risk groups. Discussion: Higher AD-related genetic risk intensified deleterious effects of diabetes on neurocognitive slowing in nondemented aging beyond the independent influence of APOE.

KW - APOE

KW - Alzheimer's disease genetic risk score

KW - Neurocognitive speed

KW - Type 2 diabetes

KW - Victoria longitudinal study

UR - http://www.scopus.com/inward/record.url?scp=84946041157&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2015.08.002

DO - 10.1016/j.dadm.2015.08.002

M3 - Article

SN - 2352-8729

VL - 1

SP - 395

EP - 402

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 4

ER -

Alzheimer's genetic risk intensifies neurocognitive slowing associated with diabetes in nondemented older adults

Abstract

Access to Document

Other files and links

Fingerprint

Cite this