Amino acid metabolism, transport and signalling in the liver revisited

Coen C. Paulusma, Wouter H. Lamers, Stefan Broer, Stan F.J. van de Graaf*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    66 Citations (Scopus)

    Abstract

    The liver controls the systemic exposure of amino acids entering via the gastro-intestinal tract. For most amino acids except branched chain amino acids, hepatic uptake is very efficient. This implies that the liver orchestrates amino acid metabolism and also controls systemic amino acid exposure. Although many amino acid transporters have been identified, cloned and investigated with respect to substrate specificity, transport mechanism, and zonal distribution, which of these players are involved in hepatocellular amino acid transport remains unclear. Here, we aim to provide a review of current insight into the molecular machinery of hepatic amino acid transport. Furthermore, we place this information in a comprehensive overview of amino acid transport, signalling and metabolism.

    Original languageEnglish
    Article number115074
    JournalBiochemical Pharmacology
    Volume201
    DOIs
    Publication statusPublished - Jul 2022

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