An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(ii) metallo-drug

Martin Huxley; Carlos Sanchez-Cano; Michael J. Browning; Carmen Navarro-Ranninger; Adoracion G. Quiroga; Alison Rodger; Michael J. Hannon

doi:10.1039/c0dt00838a

An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(ii) metallo-drug

Martin Huxley, Carlos Sanchez-Cano, Michael J. Browning, Carmen Navarro-Ranninger, Adoracion G. Quiroga, Alison Rodger, Michael J. Hannon

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

A range of androgen conjugates with non-conventional platinum(ii) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(ii) complex resulted in synergistic effects between the metallic centre and the steroidal ligand, creating highly potent platinum(ii) complexes from the inactive components.

Original language	English
Pages (from-to)	11353-11364
Number of pages	12
Journal	Dalton Transactions
Volume	39
Issue number	47
DOIs	https://doi.org/10.1039/c0dt00838a
Publication status	Published - 21 Dec 2010
Externally published	Yes

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10.1039/c0dt00838a

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AU - Huxley, Martin

AU - Sanchez-Cano, Carlos

AU - Browning, Michael J.

AU - Navarro-Ranninger, Carmen

AU - Quiroga, Adoracion G.

AU - Rodger, Alison

AU - Hannon, Michael J.

PY - 2010/12/21

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N2 - A range of androgen conjugates with non-conventional platinum(ii) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(ii) complex resulted in synergistic effects between the metallic centre and the steroidal ligand, creating highly potent platinum(ii) complexes from the inactive components.

AB - A range of androgen conjugates with non-conventional platinum(ii) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(ii) complex resulted in synergistic effects between the metallic centre and the steroidal ligand, creating highly potent platinum(ii) complexes from the inactive components.

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ER -

An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(ii) metallo-drug

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