An ellipsometric study of interaction of anti-cancer agent erufosine on lipid model systems

M. Tanovska; M. Rahmani; L. Vladimirova Mihaleva; M. Berger; D. Neshev; A. Momchilova; R. Tzoneva

doi:10.1063/1.5091376

An ellipsometric study of interaction of anti-cancer agent erufosine on lipid model systems

M. Tanovska^*, M. Rahmani, L. Vladimirova Mihaleva, M. Berger, D. Neshev, A. Momchilova, R. Tzoneva

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Citations (Scopus)

Abstract

The study of the interaction of native and model lipid membranes with pharmacological agents is a subject of outstanding interest in the research of biomaterials, biosensors, the production of devices using organic layers. In last few years, the study of biomimetic membrane systems in the form of vesicles, lipid monolayers and solid-supported lipid layers has attracted a significant attention among researchers. In this work, we present a capability of the spectroscopic ellipsometry as a novel technique to study solid - supported lipid model systems and decode the effect of the anti-cancer agent erufosine on lipids. Importantly, this technique has been proved as a fast and non-invasive method. The lipid films are composed of phosphatidylcholine, sphingomyelin and cholesterol in different concentrations and we have employed a thin gold film for supporting their surface. Erufosine (EPC3) is known as membrane-acting anti-tumor agent and in this respect has been investigated its effect on the model systems. The obtained results have revealed reorganization of lipid layers at different extent by interaction with the anti-cancer agent.

Original language	English
Title of host publication	10th Jubilee Conference of the Balkan Physical Union
Editors	Todor M. Mishonov, Albert M. Varonov
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735418035
DOIs	https://doi.org/10.1063/1.5091376
Publication status	Published - 26 Feb 2019
Event	10th Jubilee Conference of the Balkan Physical Union, BPU 2018 - Sofia, Bulgaria Duration: 26 Aug 2018 → 30 Aug 2018

Publication series

Name	AIP Conference Proceedings
Volume	2075
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	10th Jubilee Conference of the Balkan Physical Union, BPU 2018
Country/Territory	Bulgaria
City	Sofia
Period	26/08/18 → 30/08/18

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10.1063/1.5091376

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Tanovska, M., Rahmani, M., Mihaleva, L. V., Berger, M., Neshev, D., Momchilova, A., & Tzoneva, R. (2019). An ellipsometric study of interaction of anti-cancer agent erufosine on lipid model systems. In T. M. Mishonov, & A. M. Varonov (Eds.), 10th Jubilee Conference of the Balkan Physical Union Article 170011 (AIP Conference Proceedings; Vol. 2075). American Institute of Physics Inc.. https://doi.org/10.1063/1.5091376

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title = "An ellipsometric study of interaction of anti-cancer agent erufosine on lipid model systems",

abstract = "The study of the interaction of native and model lipid membranes with pharmacological agents is a subject of outstanding interest in the research of biomaterials, biosensors, the production of devices using organic layers. In last few years, the study of biomimetic membrane systems in the form of vesicles, lipid monolayers and solid-supported lipid layers has attracted a significant attention among researchers. In this work, we present a capability of the spectroscopic ellipsometry as a novel technique to study solid - supported lipid model systems and decode the effect of the anti-cancer agent erufosine on lipids. Importantly, this technique has been proved as a fast and non-invasive method. The lipid films are composed of phosphatidylcholine, sphingomyelin and cholesterol in different concentrations and we have employed a thin gold film for supporting their surface. Erufosine (EPC3) is known as membrane-acting anti-tumor agent and in this respect has been investigated its effect on the model systems. The obtained results have revealed reorganization of lipid layers at different extent by interaction with the anti-cancer agent.",

keywords = "Cholesterol, Erufosine (EPC3), Phosphatidylcholine (PC), Spectroscopic ellipsometry (SE), Sphingomyelin (SM)",

author = "M. Tanovska and M. Rahmani and Mihaleva, {L. Vladimirova} and M. Berger and D. Neshev and A. Momchilova and R. Tzoneva",

note = "Publisher Copyright: {\textcopyright} 2019 Author(s).; 10th Jubilee Conference of the Balkan Physical Union, BPU 2018 ; Conference date: 26-08-2018 Through 30-08-2018",

year = "2019",

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doi = "10.1063/1.5091376",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

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Tanovska, M, Rahmani, M, Mihaleva, LV, Berger, M, Neshev, D, Momchilova, A & Tzoneva, R 2019, An ellipsometric study of interaction of anti-cancer agent erufosine on lipid model systems. in TM Mishonov & AM Varonov (eds), 10th Jubilee Conference of the Balkan Physical Union., 170011, AIP Conference Proceedings, vol. 2075, American Institute of Physics Inc., 10th Jubilee Conference of the Balkan Physical Union, BPU 2018, Sofia, Bulgaria, 26/08/18. https://doi.org/10.1063/1.5091376

An ellipsometric study of interaction of anti-cancer agent erufosine on lipid model systems. / Tanovska, M.; Rahmani, M.; Mihaleva, L. Vladimirova et al.
10th Jubilee Conference of the Balkan Physical Union. ed. / Todor M. Mishonov; Albert M. Varonov. American Institute of Physics Inc., 2019. 170011 (AIP Conference Proceedings; Vol. 2075).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - An ellipsometric study of interaction of anti-cancer agent erufosine on lipid model systems

AU - Tanovska, M.

AU - Rahmani, M.

AU - Mihaleva, L. Vladimirova

AU - Berger, M.

AU - Neshev, D.

AU - Momchilova, A.

AU - Tzoneva, R.

PY - 2019/2/26

Y1 - 2019/2/26

N2 - The study of the interaction of native and model lipid membranes with pharmacological agents is a subject of outstanding interest in the research of biomaterials, biosensors, the production of devices using organic layers. In last few years, the study of biomimetic membrane systems in the form of vesicles, lipid monolayers and solid-supported lipid layers has attracted a significant attention among researchers. In this work, we present a capability of the spectroscopic ellipsometry as a novel technique to study solid - supported lipid model systems and decode the effect of the anti-cancer agent erufosine on lipids. Importantly, this technique has been proved as a fast and non-invasive method. The lipid films are composed of phosphatidylcholine, sphingomyelin and cholesterol in different concentrations and we have employed a thin gold film for supporting their surface. Erufosine (EPC3) is known as membrane-acting anti-tumor agent and in this respect has been investigated its effect on the model systems. The obtained results have revealed reorganization of lipid layers at different extent by interaction with the anti-cancer agent.

AB - The study of the interaction of native and model lipid membranes with pharmacological agents is a subject of outstanding interest in the research of biomaterials, biosensors, the production of devices using organic layers. In last few years, the study of biomimetic membrane systems in the form of vesicles, lipid monolayers and solid-supported lipid layers has attracted a significant attention among researchers. In this work, we present a capability of the spectroscopic ellipsometry as a novel technique to study solid - supported lipid model systems and decode the effect of the anti-cancer agent erufosine on lipids. Importantly, this technique has been proved as a fast and non-invasive method. The lipid films are composed of phosphatidylcholine, sphingomyelin and cholesterol in different concentrations and we have employed a thin gold film for supporting their surface. Erufosine (EPC3) is known as membrane-acting anti-tumor agent and in this respect has been investigated its effect on the model systems. The obtained results have revealed reorganization of lipid layers at different extent by interaction with the anti-cancer agent.

KW - Cholesterol

KW - Erufosine (EPC3)

KW - Phosphatidylcholine (PC)

KW - Spectroscopic ellipsometry (SE)

KW - Sphingomyelin (SM)

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T3 - AIP Conference Proceedings

BT - 10th Jubilee Conference of the Balkan Physical Union

A2 - Mishonov, Todor M.

A2 - Varonov, Albert M.

PB - American Institute of Physics Inc.

T2 - 10th Jubilee Conference of the Balkan Physical Union, BPU 2018

Y2 - 26 August 2018 through 30 August 2018

ER -

An ellipsometric study of interaction of anti-cancer agent erufosine on lipid model systems

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