Analogues of SB-203207 as inhibitors of tRNA synthetases

Martin G. Banwell; Curtis F. Crasto; Christopher J. Easton; Andrew K. Forrest; Tomislav Karoli; Darren R. March; Lucy Mensah; Michael R. Nairn; Peter J. O'Hanlon; Mark D. Oldham; Weimin Yue

doi:10.1016/S0960-894X(00)00456-X

Analogues of SB-203207 as inhibitors of tRNA synthetases

Martin G. Banwell, Curtis F. Crasto, Christopher J. Easton^*, Andrew K. Forrest, Tomislav Karoli, Darren R. March, Lucy Mensah, Michael R. Nairn, Peter J. O'Hanlon, Mark D. Oldham, Weimin Yue

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine and valine increased the potency of inhibition of LRS and VRS, respectively. The leucine derivative showed low level antibacterial activity, while several of the compounds inhibited IRS from Staphylococcus aureus WCUH29 more strongly than rat liver IRS. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	2263-2266
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(00)00456-X
Publication status	Published - 16 Oct 2000

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title = "Analogues of SB-203207 as inhibitors of tRNA synthetases",

abstract = "SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine and valine increased the potency of inhibition of LRS and VRS, respectively. The leucine derivative showed low level antibacterial activity, while several of the compounds inhibited IRS from Staphylococcus aureus WCUH29 more strongly than rat liver IRS. (C) 2000 Elsevier Science Ltd.",

author = "Banwell, \{Martin G.\} and Crasto, \{Curtis F.\} and Easton, \{Christopher J.\} and Forrest, \{Andrew K.\} and Tomislav Karoli and March, \{Darren R.\} and Lucy Mensah and Nairn, \{Michael R.\} and O'Hanlon, \{Peter J.\} and Oldham, \{Mark D.\} and Weimin Yue",

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doi = "10.1016/S0960-894X(00)00456-X",

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TY - JOUR

T1 - Analogues of SB-203207 as inhibitors of tRNA synthetases

AU - Banwell, Martin G.

AU - Crasto, Curtis F.

AU - Easton, Christopher J.

AU - Forrest, Andrew K.

AU - Karoli, Tomislav

AU - March, Darren R.

AU - Mensah, Lucy

AU - Nairn, Michael R.

AU - O'Hanlon, Peter J.

AU - Oldham, Mark D.

AU - Yue, Weimin

PY - 2000/10/16

Y1 - 2000/10/16

N2 - SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine and valine increased the potency of inhibition of LRS and VRS, respectively. The leucine derivative showed low level antibacterial activity, while several of the compounds inhibited IRS from Staphylococcus aureus WCUH29 more strongly than rat liver IRS. (C) 2000 Elsevier Science Ltd.

AB - SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine and valine increased the potency of inhibition of LRS and VRS, respectively. The leucine derivative showed low level antibacterial activity, while several of the compounds inhibited IRS from Staphylococcus aureus WCUH29 more strongly than rat liver IRS. (C) 2000 Elsevier Science Ltd.

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U2 - 10.1016/S0960-894X(00)00456-X

DO - 10.1016/S0960-894X(00)00456-X

M3 - Article

SN - 0960-894X

VL - 10

SP - 2263

EP - 2266

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 20

ER -

Analogues of SB-203207 as inhibitors of tRNA synthetases

Abstract

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