Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

J. A. Cavanaugh; D. F. Callen; S. R. Wilson; P. M. Stanford; M. E. Sraml; M. Gorska; J. Crawford; S. A. Whitmore; C. Shlegel; S. Foote; M. Kohonen-Corish; P. Pavli

doi:10.1017/S0003480098006976

Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

J. A. Cavanaugh, D. F. Callen, S. R. Wilson, P. M. Stanford, M. E. Sraml, M. Gorska, J. Crawford, S. A. Whitmore, C. Shlegel, S. Foote, M. Kohonen-Corish, P. Pavli

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Abstract

A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al, (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis. We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.

Original language	English
Pages (from-to)	291-298
Number of pages	8
Journal	Annals of Human Genetics
Volume	62
Issue number	4
DOIs	https://doi.org/10.1017/S0003480098006976
Publication status	Published - 1998

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Cavanaugh, J. A., Callen, D. F., Wilson, S. R., Stanford, P. M., Sraml, M. E., Gorska, M., Crawford, J., Whitmore, S. A., Shlegel, C., Foote, S., Kohonen-Corish, M., & Pavli, P. (1998). Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16. Annals of Human Genetics, 62(4), 291-298. https://doi.org/10.1017/S0003480098006976

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title = "Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16",

abstract = "A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al, (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis. We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.",

author = "Cavanaugh, {J. A.} and Callen, {D. F.} and Wilson, {S. R.} and Stanford, {P. M.} and Sraml, {M. E.} and M. Gorska and J. Crawford and Whitmore, {S. A.} and C. Shlegel and S. Foote and M. Kohonen-Corish and P. Pavli",

year = "1998",

doi = "10.1017/S0003480098006976",

language = "English",

volume = "62",

pages = "291--298",

journal = "Annals of Human Genetics",

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Cavanaugh, JA, Callen, DF, Wilson, SR, Stanford, PM, Sraml, ME, Gorska, M, Crawford, J, Whitmore, SA, Shlegel, C, Foote, S, Kohonen-Corish, M & Pavli, P 1998, 'Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16', Annals of Human Genetics, vol. 62, no. 4, pp. 291-298. https://doi.org/10.1017/S0003480098006976

TY - JOUR

T1 - Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

AU - Cavanaugh, J. A.

AU - Callen, D. F.

AU - Wilson, S. R.

AU - Stanford, P. M.

AU - Sraml, M. E.

AU - Gorska, M.

AU - Crawford, J.

AU - Whitmore, S. A.

AU - Shlegel, C.

AU - Foote, S.

AU - Kohonen-Corish, M.

AU - Pavli, P.

PY - 1998

Y1 - 1998

N2 - A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al, (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis. We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.

AB - A number of localizations for the putative susceptibility gene(s) have been identified for both Crohn's disease and ulcerative colitis. In a genome wide scan, Hugot et al, (1996) identified a region on chromosome 16 which appeared to be responsible for the inheritance of inflammatory bowel disease in a small proportion of families. Subsequent work has suggested that this localization is important for susceptibility to Crohn's disease rather than ulcerative colitis. We investigated the contribution of this localization to the inheritance of inflammatory bowel disease in 54 multiplex Australian families, and confirmed its importance in a significant proportion of Crohn's disease families; we further refined the localization to a region near to D16S409, obtaining a maximum LOD score of 6.3 between D16S409 and D16S753.

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U2 - 10.1017/S0003480098006976

DO - 10.1017/S0003480098006976

M3 - Article

SN - 0003-4800

VL - 62

SP - 291

EP - 298

JO - Annals of Human Genetics

JF - Annals of Human Genetics

IS - 4

ER -

Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16

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