Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic plasmodium falciparum parasites

Jandeli Niemand; Pieter Burger; Bianca K. Verlinden; Janette Reader; Annie M. Joubert; Annette Kaiser; Abraham I. Louw; Kiaran Kirk; Otto Phanstiel IV; Lyn Marie Birkholtz

doi:10.1128/AAC.00106-13

Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic plasmodium falciparum parasites

Jandeli Niemand, Pieter Burger, Bianca K. Verlinden, Janette Reader, Annie M. Joubert, Annette Kaiser, Abraham I. Louw, Kiaran Kirk, Otto Phanstiel IV, Lyn Marie Birkholtz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC₅₀s) in the nM to ±Mrange. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.

Original language	English
Pages (from-to)	2874-2877
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	6
DOIs	https://doi.org/10.1128/AAC.00106-13
Publication status	Published - Jun 2013

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title = "Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic plasmodium falciparum parasites",

abstract = "Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s) in the nM to ±Mrange. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.",

author = "Jandeli Niemand and Pieter Burger and Verlinden, {Bianca K.} and Janette Reader and Joubert, {Annie M.} and Annette Kaiser and Louw, {Abraham I.} and Kiaran Kirk and {Phanstiel IV}, Otto and Birkholtz, {Lyn Marie}",

year = "2013",

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language = "English",

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AU - Niemand, Jandeli

AU - Burger, Pieter

AU - Verlinden, Bianca K.

AU - Reader, Janette

AU - Joubert, Annie M.

AU - Kaiser, Annette

AU - Louw, Abraham I.

AU - Kirk, Kiaran

AU - Phanstiel IV, Otto

AU - Birkholtz, Lyn Marie

PY - 2013/6

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AB - Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s) in the nM to ±Mrange. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.

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U2 - 10.1128/AAC.00106-13

DO - 10.1128/AAC.00106-13

M3 - Article

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -

Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic plasmodium falciparum parasites

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