TY - JOUR
T1 - Anti-tuberculous therapy and acute liver failure
AU - Mitchell, Imogen
AU - Wendon, Julia
AU - Fitt, Sarah
AU - Williams, Roger
PY - 1995/3/4
Y1 - 1995/3/4
N2 - The incidence of tuberculosis has been increasing since 1987, exposing a greater number of patients to the risks of three potentially hepatotoxic drugs, isoniazid, rifampicin, and pyrazinamide. Awareness of potentially severe drug hepatotoxic reactions is vital because fulminant hepatic failure is a devastating and often fatal condition without liver transplantation. We report four cases of fulminant hepatic failure caused by rifampicin, isoniazid, or both. These cases highlight the need for stricter adherence to and review of current guidelines on liver function tests after starting anti-tuberculous therapies.
AB - The incidence of tuberculosis has been increasing since 1987, exposing a greater number of patients to the risks of three potentially hepatotoxic drugs, isoniazid, rifampicin, and pyrazinamide. Awareness of potentially severe drug hepatotoxic reactions is vital because fulminant hepatic failure is a devastating and often fatal condition without liver transplantation. We report four cases of fulminant hepatic failure caused by rifampicin, isoniazid, or both. These cases highlight the need for stricter adherence to and review of current guidelines on liver function tests after starting anti-tuberculous therapies.
UR - https://pubmed.ncbi.nlm.nih.gov/7786350/
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-0028925251&origin=resultslist&sort=plf-f&src=s&sid=dc6276b9bb6b3b1b966c251b648d7b74&sot=b&sdt=b&s=TITLE%28Anti-tuberculous+therapy+and+acute+liver+failure%29&sl=42&sessionSearchId=dc6276b9bb6b3b1b966c251b648d7b74&relpos=0
U2 - 10.1016/S0140-6736(95)90468-9
DO - 10.1016/S0140-6736(95)90468-9
M3 - Article
SN - 1474-547X
VL - 345
SP - 555
EP - 556
JO - The Lancet
JF - The Lancet
IS - 8949
ER -