Antibiotic Resistance (ABR) in Neonates with Suspected Sepsis admitted to a Medecins Sans Frontieres (MSF) supported Medium Care Unit in Quetta, Pakistan

M Fonseca; A Abdi; J Karsten; A Lenglet; C Kamau; J Fernhout; A Semple; V Burzio; T Housen

doi:10.1016/j.ijid.2018.04.3696

Antibiotic Resistance (ABR) in Neonates with Suspected Sepsis admitted to a Medecins Sans Frontieres (MSF) supported Medium Care Unit in Quetta, Pakistan

M Fonseca, A Abdi, J Karsten, A Lenglet, C Kamau, J Fernhout, A Semple, V Burzio, T Housen

Research output: Contribution to journal › Letter › peer-review

Abstract

Background: Neonatal Sepsis is a major cause of infant death, especially if associated with ABR. Choice of empirical antibiotics is particularly challenging without access to culture/DST, as in most resource limited settings. MSF care included blood cultures (BCs) since 2015. Here we describe the characteristics of babies, etiologies, ABR, treatment and outcomes.

Methods & Materials: BC was collected and antibiotics immediately started upon suspicion of sepsis, as per MSF guidelines. ABR testing was done with disc diffusion test. Proportions were compared with chi-squared test; effect of main antibiotic regimens on fatality rates (CFR) was assessed using multivariable logistic regression models (likelihood ratio test).

Results: In total 286 babies were admitted (Nov15-Jul17): 93 (32.5%) female; median age: 2 days (IQR:0-6d, range:0-30d), median gestational age: 37 weeks (IQR:36-38w, range:30-42w); median weight: 2.3Kgs (IQR:1.8-3.0Kgs, range:1-4.4Kgs), vaginal delivery: 83.9%; CPAP: 28.6%. Early onset sepsis (EOS) was suspected in 184 (64.3%) and late onset (LOS) in 102 (35.7%); 96 died (CFR: 34.4%; EOS:38.1%, LOS:26.7%; p=0.05).

Original language	English
Pages (from-to)	123-124
Journal	International Journal of Infectious Diseases
Volume	73
DOIs	https://doi.org/10.1016/j.ijid.2018.04.3696
Publication status	Published - Aug 2018

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Fonseca, M., Abdi, A., Karsten, J., Lenglet, A., Kamau, C., Fernhout, J., Semple, A., Burzio, V., & Housen, T. (2018). Antibiotic Resistance (ABR) in Neonates with Suspected Sepsis admitted to a Medecins Sans Frontieres (MSF) supported Medium Care Unit in Quetta, Pakistan. International Journal of Infectious Diseases, 73, 123-124. https://doi.org/10.1016/j.ijid.2018.04.3696

@article{dc3b6ca0f99d4118826ec1ef40428ab7,

title = "Antibiotic Resistance (ABR) in Neonates with Suspected Sepsis admitted to a Medecins Sans Frontieres (MSF) supported Medium Care Unit in Quetta, Pakistan",

abstract = "Background: Neonatal Sepsis is a major cause of infant death, especially if associated with ABR. Choice of empirical antibiotics is particularly challenging without access to culture/DST, as in most resource limited settings. MSF care included blood cultures (BCs) since 2015. Here we describe the characteristics of babies, etiologies, ABR, treatment and outcomes.Methods & Materials: BC was collected and antibiotics immediately started upon suspicion of sepsis, as per MSF guidelines. ABR testing was done with disc diffusion test. Proportions were compared with chi-squared test; effect of main antibiotic regimens on fatality rates (CFR) was assessed using multivariable logistic regression models (likelihood ratio test).Results: In total 286 babies were admitted (Nov15-Jul17): 93 (32.5%) female; median age: 2 days (IQR:0-6d, range:0-30d), median gestational age: 37 weeks (IQR:36-38w, range:30-42w); median weight: 2.3Kgs (IQR:1.8-3.0Kgs, range:1-4.4Kgs), vaginal delivery: 83.9%; CPAP: 28.6%. Early onset sepsis (EOS) was suspected in 184 (64.3%) and late onset (LOS) in 102 (35.7%); 96 died (CFR: 34.4%; EOS:38.1%, LOS:26.7%; p=0.05).",

author = "M Fonseca and A Abdi and J Karsten and A Lenglet and C Kamau and J Fernhout and A Semple and V Burzio and T Housen",

year = "2018",

month = aug,

doi = "10.1016/j.ijid.2018.04.3696",

language = "English",

volume = "73",

pages = "123--124",

journal = "International Journal of Infectious Diseases",

issn = "1201-9712",

publisher = "Elsevier B.V.",

}

Fonseca, M, Abdi, A, Karsten, J, Lenglet, A, Kamau, C, Fernhout, J, Semple, A, Burzio, V & Housen, T 2018, 'Antibiotic Resistance (ABR) in Neonates with Suspected Sepsis admitted to a Medecins Sans Frontieres (MSF) supported Medium Care Unit in Quetta, Pakistan', International Journal of Infectious Diseases, vol. 73, pp. 123-124. https://doi.org/10.1016/j.ijid.2018.04.3696

TY - JOUR

T1 - Antibiotic Resistance (ABR) in Neonates with Suspected Sepsis admitted to a Medecins Sans Frontieres (MSF) supported Medium Care Unit in Quetta, Pakistan

AU - Fonseca, M

AU - Abdi, A

AU - Karsten, J

AU - Lenglet, A

AU - Kamau, C

AU - Fernhout, J

AU - Semple, A

AU - Burzio, V

AU - Housen, T

PY - 2018/8

Y1 - 2018/8

N2 - Background: Neonatal Sepsis is a major cause of infant death, especially if associated with ABR. Choice of empirical antibiotics is particularly challenging without access to culture/DST, as in most resource limited settings. MSF care included blood cultures (BCs) since 2015. Here we describe the characteristics of babies, etiologies, ABR, treatment and outcomes.Methods & Materials: BC was collected and antibiotics immediately started upon suspicion of sepsis, as per MSF guidelines. ABR testing was done with disc diffusion test. Proportions were compared with chi-squared test; effect of main antibiotic regimens on fatality rates (CFR) was assessed using multivariable logistic regression models (likelihood ratio test).Results: In total 286 babies were admitted (Nov15-Jul17): 93 (32.5%) female; median age: 2 days (IQR:0-6d, range:0-30d), median gestational age: 37 weeks (IQR:36-38w, range:30-42w); median weight: 2.3Kgs (IQR:1.8-3.0Kgs, range:1-4.4Kgs), vaginal delivery: 83.9%; CPAP: 28.6%. Early onset sepsis (EOS) was suspected in 184 (64.3%) and late onset (LOS) in 102 (35.7%); 96 died (CFR: 34.4%; EOS:38.1%, LOS:26.7%; p=0.05).

AB - Background: Neonatal Sepsis is a major cause of infant death, especially if associated with ABR. Choice of empirical antibiotics is particularly challenging without access to culture/DST, as in most resource limited settings. MSF care included blood cultures (BCs) since 2015. Here we describe the characteristics of babies, etiologies, ABR, treatment and outcomes.Methods & Materials: BC was collected and antibiotics immediately started upon suspicion of sepsis, as per MSF guidelines. ABR testing was done with disc diffusion test. Proportions were compared with chi-squared test; effect of main antibiotic regimens on fatality rates (CFR) was assessed using multivariable logistic regression models (likelihood ratio test).Results: In total 286 babies were admitted (Nov15-Jul17): 93 (32.5%) female; median age: 2 days (IQR:0-6d, range:0-30d), median gestational age: 37 weeks (IQR:36-38w, range:30-42w); median weight: 2.3Kgs (IQR:1.8-3.0Kgs, range:1-4.4Kgs), vaginal delivery: 83.9%; CPAP: 28.6%. Early onset sepsis (EOS) was suspected in 184 (64.3%) and late onset (LOS) in 102 (35.7%); 96 died (CFR: 34.4%; EOS:38.1%, LOS:26.7%; p=0.05).

U2 - 10.1016/j.ijid.2018.04.3696

DO - 10.1016/j.ijid.2018.04.3696

M3 - Letter

SN - 1201-9712

VL - 73

SP - 123

EP - 124

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

ER -

Antibiotic Resistance (ABR) in Neonates with Suspected Sepsis admitted to a Medecins Sans Frontieres (MSF) supported Medium Care Unit in Quetta, Pakistan

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