Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae

Chunjiu Zhao, Rodney W. Rickards, Stephen C. Trowell

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    22 Citations (Scopus)

    Abstract

    The antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.

    Original languageEnglish
    Pages (from-to)10753-10759
    Number of pages7
    JournalTetrahedron
    Volume60
    Issue number47
    DOIs
    Publication statusPublished - 15 Nov 2004

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