Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae

Chunjiu Zhao; Rodney W. Rickards; Stephen C. Trowell

doi:10.1016/j.tet.2004.08.065

Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae

Chunjiu Zhao, Rodney W. Rickards, Stephen C. Trowell

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.

Original language	English
Pages (from-to)	10753-10759
Number of pages	7
Journal	Tetrahedron
Volume	60
Issue number	47
DOIs	https://doi.org/10.1016/j.tet.2004.08.065
Publication status	Published - 15 Nov 2004

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title = "Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae",

abstract = "The antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.",

keywords = "Antibacterial, Diterpene, Nasutitermes triodiae, Termite, Trinervitadiene, Trinervitane",

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AU - Rickards, Rodney W.

AU - Trowell, Stephen C.

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AB - The antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.

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JO - Tetrahedron

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Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae

Abstract

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