Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae

Chunjiu Zhao; Rodney W. Rickards; Stephen C. Trowell

doi:10.1016/j.tet.2004.08.065

Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae

Chunjiu Zhao, Rodney W. Rickards, Stephen C. Trowell

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.

Original language	English
Pages (from-to)	10753-10759
Number of pages	7
Journal	Tetrahedron
Volume	60
Issue number	47
DOIs	https://doi.org/10.1016/j.tet.2004.08.065
Publication status	Published - 15 Nov 2004

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10.1016/j.tet.2004.08.065

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title = "Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae",

abstract = "The antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.",

keywords = "Antibacterial, Diterpene, Nasutitermes triodiae, Termite, Trinervitadiene, Trinervitane",

author = "Chunjiu Zhao and Rickards, \{Rodney W.\} and Trowell, \{Stephen C.\}",

year = "2004",

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doi = "10.1016/j.tet.2004.08.065",

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T1 - Antibiotics from Australian terrestrial invertebrates. Part 1

T2 - Antibacterial trinervitadienes from the termite Nasutitermes triodiae

AU - Zhao, Chunjiu

AU - Rickards, Rodney W.

AU - Trowell, Stephen C.

PY - 2004/11/15

Y1 - 2004/11/15

N2 - The antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.

AB - The antibacterial activity of an extract of the Australian termite Nasutitermes triodiae (Isoptera: Termitidae) (Froggatt) is due to the presence of a group of trinervitanes, diterpenes unique to termite genera within the subfamily Nasutitermitinae. The major active components are novel hydroxylated 1(15),8(19)-trinervitadienes and the known 1(15),8(9)-trinervitadiene-2β, 3α-diol. This constitutes the first observation of hydroxylation of the trinervitane skeleton at the 5- and 18-positions, and of the substantial antimicrobial activity of trinervitane diterpenes. Graphical Abstract.

KW - Antibacterial

KW - Diterpene

KW - Nasutitermes triodiae

KW - Termite

KW - Trinervitadiene

KW - Trinervitane

UR - https://www.scopus.com/pages/publications/5644302250

U2 - 10.1016/j.tet.2004.08.065

DO - 10.1016/j.tet.2004.08.065

M3 - Article

SN - 0040-4020

VL - 60

SP - 10753

EP - 10759

JO - Tetrahedron

JF - Tetrahedron

IS - 47

ER -

Antibiotics from Australian terrestrial invertebrates. Part 1: Antibacterial trinervitadienes from the termite Nasutitermes triodiae

Abstract

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