Antileishmanial polyphenols from Corymbia maculata

Jasmeen Sidana, Dinesh Neeradi, Alka Choudhary, Sushma Singh, William J. Foley, Inder Pal Singh*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    An activity-guided fractionation was used to identify the antileishmanial compounds of Corymbia maculata. The hexane, ethyl acetate and methanol extracts were active in in vitro antileishmanial assay. Twelve polyphenols including 8-demethyl eucalyptin (1), eucalyptin (2), myrciaphenone A (3), myrciaphenone B (4), quercetin-3-O-β-d-xylopyranoside (5), myricetin-3-O-α-l- rhamnopyranoside (6), quercetin-3-O-β-d-galactopyranoside (7), quercetin-3-O-β-d-glucopyranoside (8), quercetin-3-O-α-l- rhamnopyranoside (9), syringic acid (10), gallic acid-3-methyl ether (11), gallic acid-4-methyl ether (12) and gallic acid (13) were isolated from the active extracts. All the tested compounds except 8-demethyleucalyptin and myrciaphenone B showed strong to moderate (6.9-24.5 μM) antileishmanial activity against Leishmania donovani promastigotes. An HPLC-PDA method has been developed to detect/quantify 29 compounds in the extracts of C. maculata leaves. This validated method allows simultaneous quantitation of seven flavonoids, fourteen phloroglucinols and eight other polyphenols and can be applied for qualitative as well as quantitative determination of phytoconstituents in Eucalyptus matrices. [Figure not available: see fulltext.]

    Original languageEnglish
    Pages (from-to)765-775
    Number of pages11
    JournalJournal of Chemical Sciences
    Volume125
    Issue number4
    DOIs
    Publication statusPublished - Jul 2013

    Fingerprint

    Dive into the research topics of 'Antileishmanial polyphenols from Corymbia maculata'. Together they form a unique fingerprint.

    Cite this