TY - JOUR
T1 - Antimicrobial and cytotoxic activities of synthetically derived tambjamines C and E-J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata
AU - Pinkerton, David M.
AU - Banwell, Martin G.
AU - Garson, Mary J.
AU - Kumar, Naresh
AU - De Moraes, Manoel Odorico
AU - Cavalcanti, Bruno C.
AU - Barros, Francisco W.A.
AU - Pessoa, Cláudia
PY - 2010/5
Y1 - 2010/5
N2 - In the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1-9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various human cancer cell lines. Most were strongly active against the fungus Malassezia furfur (>amphotericin B) and showed considerable, but non-selective, antiproliferative activity against both human cancer and normal cell lines. Tambjamines I and J (6 and 7, resp.) displayed significant apoptosis-inducing effects.
AB - In the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1-9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various human cancer cell lines. Most were strongly active against the fungus Malassezia furfur (>amphotericin B) and showed considerable, but non-selective, antiproliferative activity against both human cancer and normal cell lines. Tambjamines I and J (6 and 7, resp.) displayed significant apoptosis-inducing effects.
UR - http://www.scopus.com/inward/record.url?scp=77952762071&partnerID=8YFLogxK
U2 - 10.1002/cbdv.201000030
DO - 10.1002/cbdv.201000030
M3 - Article
SN - 1612-1872
VL - 7
SP - 1311
EP - 1324
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 5
ER -