Antimicrobial Resistance of Campylobacter spp. Causing Human Infection in Australia: An International Comparison

Rhiannon L. Wallace, Dieter Bulach, Angus McLure, Liana Varrone, Amy V. Jennison, Mary Valcanis, James J. Smith, Benjamin G. Polkinghorne, Kathryn Glass, Martyn D. Kirk*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    The study investigates the prevalence of antimicrobial resistance in Campylobacter jejuni and Campylobacter coli in gastroenteritis patients in the eight most populous regions in Australia and compares the prevalence of antimicrobial resistance in Europe and North America. A total of 164 Campylobacter isolates were collected from patients with campylobacteriosis and tested for susceptibility to six antimicrobials using ETEST® strips and compared with reports from Europe and the United States. Genomes were sequenced on Illumina NextSeq to identify genetic determinants of resistance. Phenotypically, 1.8%, 14.0%, 14.6%, and 20.1% of isolates were resistant to erythromycin (ERY), ampicillin, tetracycline (TET), and ciprofloxacin (CIP), respectively. Comparing published phenotypic results of antimicrobial resistance in several European countries and the United States with these Australian isolates reveals that rates observed in Australia are among the lowest observed for ERY, CIP, and TET for both C. coli and C. jejuni. For each antimicrobial tested, concordance between resistance phenotype and genotype ranged from 66.6% to 100.0%. This study highlights that, among industrialized countries, Portugal and Spain have very high levels of antimicrobial resistance in C. jejuni and C. coli, especially when compared with the United Kingdom, United States, and Australia.

    Original languageEnglish
    Pages (from-to)518-528
    Number of pages11
    JournalMicrobial Drug Resistance
    Volume27
    Issue number4
    DOIs
    Publication statusPublished - 1 Apr 2021

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