TY - JOUR
T1 - Antimicrobial Resistance of Campylobacter spp. Causing Human Infection in Australia
T2 - An International Comparison
AU - Wallace, Rhiannon L.
AU - Bulach, Dieter
AU - McLure, Angus
AU - Varrone, Liana
AU - Jennison, Amy V.
AU - Valcanis, Mary
AU - Smith, James J.
AU - Polkinghorne, Benjamin G.
AU - Glass, Kathryn
AU - Kirk, Martyn D.
N1 - Publisher Copyright:
© Copyright 2021, Mary Ann Liebert, Inc., publishers 2021.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - The study investigates the prevalence of antimicrobial resistance in Campylobacter jejuni and Campylobacter coli in gastroenteritis patients in the eight most populous regions in Australia and compares the prevalence of antimicrobial resistance in Europe and North America. A total of 164 Campylobacter isolates were collected from patients with campylobacteriosis and tested for susceptibility to six antimicrobials using ETEST® strips and compared with reports from Europe and the United States. Genomes were sequenced on Illumina NextSeq to identify genetic determinants of resistance. Phenotypically, 1.8%, 14.0%, 14.6%, and 20.1% of isolates were resistant to erythromycin (ERY), ampicillin, tetracycline (TET), and ciprofloxacin (CIP), respectively. Comparing published phenotypic results of antimicrobial resistance in several European countries and the United States with these Australian isolates reveals that rates observed in Australia are among the lowest observed for ERY, CIP, and TET for both C. coli and C. jejuni. For each antimicrobial tested, concordance between resistance phenotype and genotype ranged from 66.6% to 100.0%. This study highlights that, among industrialized countries, Portugal and Spain have very high levels of antimicrobial resistance in C. jejuni and C. coli, especially when compared with the United Kingdom, United States, and Australia.
AB - The study investigates the prevalence of antimicrobial resistance in Campylobacter jejuni and Campylobacter coli in gastroenteritis patients in the eight most populous regions in Australia and compares the prevalence of antimicrobial resistance in Europe and North America. A total of 164 Campylobacter isolates were collected from patients with campylobacteriosis and tested for susceptibility to six antimicrobials using ETEST® strips and compared with reports from Europe and the United States. Genomes were sequenced on Illumina NextSeq to identify genetic determinants of resistance. Phenotypically, 1.8%, 14.0%, 14.6%, and 20.1% of isolates were resistant to erythromycin (ERY), ampicillin, tetracycline (TET), and ciprofloxacin (CIP), respectively. Comparing published phenotypic results of antimicrobial resistance in several European countries and the United States with these Australian isolates reveals that rates observed in Australia are among the lowest observed for ERY, CIP, and TET for both C. coli and C. jejuni. For each antimicrobial tested, concordance between resistance phenotype and genotype ranged from 66.6% to 100.0%. This study highlights that, among industrialized countries, Portugal and Spain have very high levels of antimicrobial resistance in C. jejuni and C. coli, especially when compared with the United Kingdom, United States, and Australia.
KW - Campylobacter
KW - antimicrobial resistance
KW - erm(B)
KW - erythromycin
KW - whole genome sequencing (WGS)
UR - http://www.scopus.com/inward/record.url?scp=85104500442&partnerID=8YFLogxK
U2 - 10.1089/mdr.2020.0082
DO - 10.1089/mdr.2020.0082
M3 - Article
SN - 1076-6294
VL - 27
SP - 518
EP - 528
JO - Microbial Drug Resistance
JF - Microbial Drug Resistance
IS - 4
ER -