TY - JOUR
T1 - Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats
AU - Schyvens, Christopher G.
AU - Andrews, Miles C.
AU - Tam, Rachel
AU - Mori, Trevor A.
AU - Croft, Kevin D.
AU - McKenzie, Katja U.S.
AU - Whitworth, Judith A.
AU - Zhang, Yi
PY - 2007/9
Y1 - 2007/9
N2 - This study examined whether the anti-oxidants ascorbic acid, α- or γ-tocopherol, could modify adrenocorticotrophic hormone (ACTH)-hypertension in Sprague-Dawley rats, a model associated with increased oxidative stress. Systolic blood pressure (SBP) was measured by the tail-cuff method. After four days of ascorbic acid (AA) (200mg/kg/day drinking) or α-tocopherol (500 mg/kg/d i.p. or feed), rats were co-administered ACTH (0.2 mg/kg/day s.c.) or saline for 11 days (prevention studies). In reversal studies, ACTH/saline was administered for 15 days, and from day 9, α- or γ-tocopherol (20 mg/kg/day) was added. ACTH increased SBP compared to saline (p < 0.05). AA or α-tocopherol failed to prevent and α- or γ-tocopherol failed to reverse ACTH-induced hypertension. Thus, neither vitamin C (water soluble) nor E (lipid soluble) modified ACTH-induced hypertension in the rat.
AB - This study examined whether the anti-oxidants ascorbic acid, α- or γ-tocopherol, could modify adrenocorticotrophic hormone (ACTH)-hypertension in Sprague-Dawley rats, a model associated with increased oxidative stress. Systolic blood pressure (SBP) was measured by the tail-cuff method. After four days of ascorbic acid (AA) (200mg/kg/day drinking) or α-tocopherol (500 mg/kg/d i.p. or feed), rats were co-administered ACTH (0.2 mg/kg/day s.c.) or saline for 11 days (prevention studies). In reversal studies, ACTH/saline was administered for 15 days, and from day 9, α- or γ-tocopherol (20 mg/kg/day) was added. ACTH increased SBP compared to saline (p < 0.05). AA or α-tocopherol failed to prevent and α- or γ-tocopherol failed to reverse ACTH-induced hypertension. Thus, neither vitamin C (water soluble) nor E (lipid soluble) modified ACTH-induced hypertension in the rat.
KW - Ascorbic acid
KW - Hypertension
KW - Tocopherol
UR - http://www.scopus.com/inward/record.url?scp=36248948591&partnerID=8YFLogxK
U2 - 10.1080/10641960701615774
DO - 10.1080/10641960701615774
M3 - Article
SN - 1064-1963
VL - 29
SP - 465
EP - 478
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 7
ER -