Antiphospholipid antibodies and stroke in Down syndrome

P. Gatenby*, R. Tuck, C. Andrews, R. O'Neil

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Two patients with Down syndrome and the primary antiphospholipid antibody are described. One patient had a vasculopathy similar to that previously described as Moyamoya. Down syndrome is characterized by immune defects including a tendency to autoimmune phenomena. This report extends the scope of these observations and particularly draws out the potential role of antiphospholipid antibodies. Indeed antiphospholipid antibodies may well explain the well-known association of Down syndrome and stroke.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
Issue number1
Publication statusPublished - 2003
Externally publishedYes


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