Apathy associated with neurocognitive disorders: Recent progress and future directions

Krista L. Lanctôt; Luis Agüera-Ortiz; Henry Brodaty; Paul T. Francis; Yonas E. Geda; Zahinoor Ismail; Gad A. Marshall; Moyra E. Mortby; Chiadi U. Onyike; Prasad R. Padala; Antonios M. Politis; Paul B. Rosenberg; Emma Siegel; David L. Sultzer; Eleenor H. Abraham

doi:10.1016/j.jalz.2016.05.008

Apathy associated with neurocognitive disorders: Recent progress and future directions

Krista L. Lanctôt^*, Luis Agüera-Ortiz, Henry Brodaty, Paul T. Francis, Yonas E. Geda, Zahinoor Ismail, Gad A. Marshall, Moyra E. Mortby, Chiadi U. Onyike, Prasad R. Padala, Antonios M. Politis, Paul B. Rosenberg, Emma Siegel, David L. Sultzer, Eleenor H. Abraham

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

165 Citations (Scopus)

Abstract

Introduction Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities. Methods The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs. Results Progress has recently been made in three areas relevant to apathy: (1) phenomenology, including the use of diagnostic criteria and novel instruments for measurement, (2) neurobiology, including neuroimaging, neuropathological and biomarker correlates, and (3) interventions, including pharmacologic, nonpharmacologic, and noninvasive neuromodulatory approaches. Discussion Recent progress confirms that apathy has a significant impact on those with major NCD and those with mild NCDs. As such, it is an important target for research and intervention.

Original language	English
Pages (from-to)	84-100
Number of pages	17
Journal	Alzheimer's and Dementia
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/j.jalz.2016.05.008
Publication status	Published - 1 Jan 2017

Access to Document

10.1016/j.jalz.2016.05.008

Cite this

Lanctôt, K. L., Agüera-Ortiz, L., Brodaty, H., Francis, P. T., Geda, Y. E., Ismail, Z., Marshall, G. A., Mortby, M. E., Onyike, C. U., Padala, P. R., Politis, A. M., Rosenberg, P. B., Siegel, E., Sultzer, D. L., & Abraham, E. H. (2017). Apathy associated with neurocognitive disorders: Recent progress and future directions. Alzheimer's and Dementia, 13(1), 84-100. https://doi.org/10.1016/j.jalz.2016.05.008

@article{b14dbba06a9448b391ff72368acf45bb,

title = "Apathy associated with neurocognitive disorders: Recent progress and future directions",

abstract = "Introduction Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities. Methods The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs. Results Progress has recently been made in three areas relevant to apathy: (1) phenomenology, including the use of diagnostic criteria and novel instruments for measurement, (2) neurobiology, including neuroimaging, neuropathological and biomarker correlates, and (3) interventions, including pharmacologic, nonpharmacologic, and noninvasive neuromodulatory approaches. Discussion Recent progress confirms that apathy has a significant impact on those with major NCD and those with mild NCDs. As such, it is an important target for research and intervention.",

keywords = "Alzheimer's disease (AD), Apathy, Mild behavioral impairment (MBI), Neurocognitive disorders (NCD), neuropsychiatric symptoms (NPS)",

author = "Lanct{\^o}t, {Krista L.} and Luis Ag{\"u}era-Ortiz and Henry Brodaty and Francis, {Paul T.} and Geda, {Yonas E.} and Zahinoor Ismail and Marshall, {Gad A.} and Mortby, {Moyra E.} and Onyike, {Chiadi U.} and Padala, {Prasad R.} and Politis, {Antonios M.} and Rosenberg, {Paul B.} and Emma Siegel and Sultzer, {David L.} and Abraham, {Eleenor H.}",

note = "Publisher Copyright: {\textcopyright} 2016 the Alzheimer's Association",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/j.jalz.2016.05.008",

language = "English",

volume = "13",

pages = "84--100",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

Lanctôt, KL, Agüera-Ortiz, L, Brodaty, H, Francis, PT, Geda, YE, Ismail, Z, Marshall, GA, Mortby, ME, Onyike, CU, Padala, PR, Politis, AM, Rosenberg, PB, Siegel, E, Sultzer, DL & Abraham, EH 2017, 'Apathy associated with neurocognitive disorders: Recent progress and future directions', Alzheimer's and Dementia, vol. 13, no. 1, pp. 84-100. https://doi.org/10.1016/j.jalz.2016.05.008

TY - JOUR

T1 - Apathy associated with neurocognitive disorders

T2 - Recent progress and future directions

AU - Lanctôt, Krista L.

AU - Agüera-Ortiz, Luis

AU - Brodaty, Henry

AU - Francis, Paul T.

AU - Geda, Yonas E.

AU - Ismail, Zahinoor

AU - Marshall, Gad A.

AU - Mortby, Moyra E.

AU - Onyike, Chiadi U.

AU - Padala, Prasad R.

AU - Politis, Antonios M.

AU - Rosenberg, Paul B.

AU - Siegel, Emma

AU - Sultzer, David L.

AU - Abraham, Eleenor H.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Introduction Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities. Methods The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs. Results Progress has recently been made in three areas relevant to apathy: (1) phenomenology, including the use of diagnostic criteria and novel instruments for measurement, (2) neurobiology, including neuroimaging, neuropathological and biomarker correlates, and (3) interventions, including pharmacologic, nonpharmacologic, and noninvasive neuromodulatory approaches. Discussion Recent progress confirms that apathy has a significant impact on those with major NCD and those with mild NCDs. As such, it is an important target for research and intervention.

AB - Introduction Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities. Methods The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs. Results Progress has recently been made in three areas relevant to apathy: (1) phenomenology, including the use of diagnostic criteria and novel instruments for measurement, (2) neurobiology, including neuroimaging, neuropathological and biomarker correlates, and (3) interventions, including pharmacologic, nonpharmacologic, and noninvasive neuromodulatory approaches. Discussion Recent progress confirms that apathy has a significant impact on those with major NCD and those with mild NCDs. As such, it is an important target for research and intervention.

KW - Alzheimer's disease (AD)

KW - Apathy

KW - Mild behavioral impairment (MBI)

KW - Neurocognitive disorders (NCD)

KW - neuropsychiatric symptoms (NPS)

UR - http://www.scopus.com/inward/record.url?scp=84996773938&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2016.05.008

DO - 10.1016/j.jalz.2016.05.008

M3 - Review article

SN - 1552-5260

VL - 13

SP - 84

EP - 100

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 1

ER -

Apathy associated with neurocognitive disorders: Recent progress and future directions

Abstract

Access to Document

Other files and links

Fingerprint

Cite this